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アイソトープ総合センター 業績集


 2016 年

 2015 年

 2014 年

 2013 年

 2012 年

 2011 年

 2010 年



2016

【 英 文 原 著 論 文 】

  1. Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki N, Higashikawa K, Yasui H, Kuge Y: Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft. EJNMMI Res. 2016; 6(1): 90.

  2. Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima K, Magota K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy. Eur J Nucl Med Mol Imaging. 2016; 43(12): 2147-2154.

  3. Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y: Optimization of helical acquisition parameters to preserve uniformity of mouse whole body using multipinhole collimator in single-photon emission computed tomography. Results in Physics. 2016; 6: 659-663.

  4. Masaki Y, Shimizu Y, Yoshioka T, Feng F, Zhao S, Higashino K, Numata Y, Kuge Y: Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016; 11(8): e0161639.

  5. Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Ken-Ichi N, Tamaki N, Kuge Y: The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine. J Nucl Med. 2016; 57(8): 1276-81.

  6. Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R, Nakanishi H, Ozeki E, Kuge Y, Saji H. Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. PLoS One. 2016; 11(7) :e0159303.

  7. Toyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N: 18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumors. Eur J Nucl Med Mol Imaging. 2016 Jul;43(8):1469-76.

  8. Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y: Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochim Biophys Acta. 2016; 1861(8 Pt A): 688-702.

  9. Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y: Imaging mass spectrometry reveals acyl-chain- and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice. PLoS One. 2016; 11(3): e0152191.

【 英 文 総 説 】

  1. Shimizu Y, Kuge Y: Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging. Nuclear Medicine and Molecular Imaging. Nuclear Medicine and Molecular Imaging, 2016; 50(4): 284-291.

【 英 文 編 書 】

  1. Kuge Y, Shiga T, Tamaki N (eds.) “Molecular Imaging for Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy”, Springer (Springer Science+Business Media), Heidelberger, 2016.

【 英 文 著 書 】

  1. Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N: Semiconductor Detector-Based Scanners for Nuclear Medicine. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;51-65.

  2. Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y: Development of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography Probe. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;113-124.

  3. Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y: Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 125-130.

  4. Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki N, Kuge Y: Discovery and Evaluation of Biomarkers for Atherosclerosis. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 131-139.

  5. Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y: Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 141-150.

【 和 文 著 書 】

  1. 久下裕司:Ⅰ核医学で知っておくべき最低限の基礎知識 A放射能・放射線の基礎。玉木長良、真鍋治編集 わかりやすい核医学。文光堂、東京、2016, pp2-8.

  2. 久下裕司:Ⅰ核医学で知っておくべき最低限の基礎知識 B放射性医薬品。玉木長良、真鍋治編集 わかりやすい核医学。文光堂、東京、2016, pp9-15.

  3. 久下裕司:第2章 放射性医薬品。日本放射線技術学会 監修、大西秀雄・市原 隆・山本智朗 共編、放射線技術学シリーズ:核医学検査技術学 第3版、オーム社、東京、2016, pp.38-45.




2015

【 著 書 】

  1. 久下裕司:第8章 4. PETの化学,日本放射線技術学会 監修,東 静香,久保直樹 共編,放射線技術学シリーズ:放射化学第3版,オーム社,東京,2015, pp.152-163.

  2. 久下裕司:第8章 5.分子イメージング,日本放射線技術学会 監修,花田博之 編著,放射線技術学シリーズ:放射化学第3版,オーム社,東京,2015, pp.163-166.


【 英 文 論 文 な ど 】

  1. Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M: Regulatory effect of interleukin-4 in the innate inflammatory response to Rhodococcus aurantiacus infection in mice. J Interferon Cytokine Res. 35(3): 222-231, 2015.

  2. Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki N: Oli-godendroglial component complicates the prediction of tumour grading with metabolic imaging. Eur J Nucl Med Mol Imaging. 42(6): 896-904, 2015

  3. Kobayashi K, Hirata K, Yamaguchi S, Manabe O, Terasaka S, Kobayashi H, Shiga T, Hattori N, Tanaka S, Kuge Y, Tamaki N: Prognostic value of volume-based measurements on (11)C-methionine PET in glioma patients. Eur J Nucl Med Mol Imaging. 42(7): 1071-1080, 2015

  4. Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y: Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med. 29(7): 582-587, 2015

  5. Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y: Combined plasma and tissue proteomic study of atherogenic model mouse: approach to eucidate mlecular dterminants in aherosclerosis dvelopment. J Proteome Res. 14(10): 4257-4269, 2015

  6. Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y: The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites. Sci Rep. 2015; 5:16802

  7. Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino H, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y: Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. Biochim Biophys Acta. 2015; 1851(12): 1554-65.

  8. Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H: Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[(11)C]Methylation with [(11)C]CH3I: Rapid Synthesis of [(11)C]Raclopride. Chem Pharm Bull (Tokyo). 2015; 63(9): 737-40.

  9. Yamaguchi A, Hanaoka H, Fujisawa Y, Zhao S, Suzue K, Morita A, Tominaga H, Higuchi T, Hisaeda H, Tsushima Y, Kuge Y, Iida Y: Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography. EJNMMI Res. 2015; 5: 29

  10. Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y: Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: Evaluation of hepatic distribution and metabolism in mice at various metabolic status induced by fasting in comparison with palmitic acid. Mol Imaging. 2015; 14(0): 1-11.

  11. Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y: Irbesartan attenuates atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits: Noninvasive imaging of inflammation by 18F-FDG PET. Mol Imaging. 2015; 14(0): 1-8

【 総 説 な ど 】

  1. 久下裕司,西嶋剣一,大倉一枝,志賀哲,玉木長良:イメージングによる“がん”の治療効果予測―新規核医学診断薬([123I]IIMU)の臨床研究への歩み,ISOTOPE NEWS 729; 16-20, 2015

  2. 杉本正志,志水陽一,五十嵐靖之,久下裕司:イメージング質量分析を用いたスフィンゴミエリンの組織内分布と制御機構の解明,日本分子イメージング学会機関誌JSMI Report. 2015:9(1): 43-45




2014 年

【 英 文 論 文 な ど 】

  1. Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y: Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLOS One. 2014; 9(1): e86426.

  2. Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida T, Takemoto H, Tamaki N, Kuge Y: Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging with 14C-FDG and 99mTc-annexin A5. PLOS One. 2014; 9(2): e89338.

  3. Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada T, Horiguchi M, Hatate C, Kuge Y, Miwa S: A simple and rapid method for standard preparation of gas phase extract of cigarette smoke. PLOS ONE. 2014; 9(9): e107856.

  4. Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga T, Kuge Y, Tamaki N:Evaluation of delineation of image details in semiconductor PET utilizing the normalized mutual information technique;Nuclear Medicine Communications . 2014; 35(6): 677-682.

  5. Fatema CN, Zhao S, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y: Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer zerografts using radiolabaled FMISO and FLT. BMC Cancer. 2014; 14(1): 692.

  6. Oshima N, Akizawa H, Zhao S, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K: Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives. Bioorgan Med Chem. 2014; 22(4): 1377-1382.

  7. Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki N: Collimator for variable sensitivity and spatial resolution without the need for exchange. IEEE Trans Nucl Sci. 2014; 61(5): 2489-2493.

  8. 野矢 洋一, 阿保 憲史, 志水 陽一, 久保 直樹, 久下 裕司: 放射線施設の建替えに関する構想について. 日本放射線安全管理学会誌. 2014; 13(1): 51-54.

  9. Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H: In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel Activatable Near-Infrared Fluorescence Probe. Cancer Science. 2014; 105: 1056-62.

  10. Onoe S, Temma T, Shimizu Y, Ono M, Saji H: Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors. Cancer Medicine. 2014; 3: 775-86.

  11. Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji H: Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging of Cancer Biomolecules. Nanomedicine: Nanotechnology, Biology and Medicine. 2014; 10: 187-95.



2013 年

【 著 書 】

  1. 久保直樹:第4章核医学検査技術学。オーム社編。2014年版診療放射線技師国家試験合格! Myテキスト。オーム社編集、オーム社、東京、2013, pp145-196.



【 英 文 論 文 な ど 】

  1. Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S: 123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain. Stroke. 2013; 44(10): 2869-74.

  2. Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita H, Iwakiri T, Koshimoto C, Kawai K, Tamaki N, Kuge Y, Asada Y. 18F-FDG uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions. Circ J. 2013; 77(10): 2626-35.

  3. Zhao Y, Zhao S, Kuge Y, Tamaki N: Elevated 18F-FDG levels in blood and organs following angiotensin II receptor blocker administration: Experiment in mice administered telmisartan. J Nucl Med. 2013; 54(8): 1384-8.

  4. Murakami M, Zhao S, Zhao Y, Fatema CN, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y: Increased intratumoral fluorothymidine (FLT) uptake level after multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft. Oncol Lett. 2013; 6(3): 667-672.

  5. Noya Y, Seki KI, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S: Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity. Toxicology. 2013; 314(1): 1-10.

  6. Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Akita H, Tamaki N: Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression. BMC Cancer 2013; 13(1): 525.

  7. Yi M, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N: Contribution of Toll-Like Receptor 2 to the Response against Staphylococcus aureus Infection in Mice. PloS One. 2013; 8 (9): e74287.

  8. Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Inanami O. Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model. Biochem Biophys Res Commun. 2013; 437(3): 420-425.

  9. Sato J, Kitagawa Y, Yamazaki Y, Hata H, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N: 18F-Fluoromisonidazole PET Uptake Is Correlated with Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma. J Nucl Med. 2013; 54(7): 1060-5.

  10. Kawai T, Kawashima H, Kuge Y, Saji H: Synthesis and evaluation of 11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer's disease brain. Nucl Med Biol. 2013; 40(5): 705-9.

  11. Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Attenuation of apotosis by telmisartan in atherosclerotic plaques of apoE-/- mice: evaluation using 99mTc-annexin A5. Mol Imaging. 2013; 12(5): 300-9.

  12. Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa Y, Kuge Y: Monitoring tumor proliferative response to radiotherapy using 18F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67. Ann Nucl Med. 2013; 27(4): 355-62.

  13. Oashi K, Furukawa H, Nishihara H, Ozaki M, Oyama A, Funayama E, Hayashi T, Kuge Y, Yamamoto Y: Pathophysiological Characteristics of Melanoma In-Transit Metastasis in a Lymphedema Mouse Model. J Invest Dermatol. 2013; 133(2): 537-44

  14. Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N: High Reproducibility of Tumor Hypoxia Evaluated by 18F-Fluoromisonidazole PET for Head and Neck Cancer. J Nucl Med. 2013; 54(2): 201-7.

  15. Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N Kuge Y: Biological characteristics of intratumoral [F-18]fluoromisonidazole distribution in a rodent model of glioma. Int J Oncol. 2013; 42(3): 823-30.

  16. Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N: Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct. Neuropathology. 2013; 33(2): 140-8.

  17. Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R, Takeuchi W, Kuge Y, Tamaki N, Shirato H: [(18)F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer. Int J Radiat Oncol Biol Phys. 2013; 85(1): 142-7

  18. Miyamoto M, Kuroda S, Zhao S, Magota K, Maruichi K, Ito M, Kawabori M, Shichinohe H, Houkin K, Kuge Y, Tamaki N. Bone Marrow Stromal Cells Transplantation Enhances Recovery of Local Glucose Metabolism after Cerebral Infarct in Rats: A Serial 18F-FDG PET Study. J Nucl Med. 2013; 54(1): 145-50.

  19. Suzuki A, Takeuchi W, Ishitsu T, Tsuchiya K, Morimoto Y, Ueno Y, Kobashi K, Kubo N, Shiga T, Tamaki N: High-sensitivity brain SPECT system using cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator. Phys Med Biol. 2013;58(21):7715-31.

  20. Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, Ono M, Saji H.Miniaturized Antibodies for Imaging Membrane Type-1 Matrix Metalloproteinase in CancersCancer Sci. 104(4):495-501 (2013).



【 総 説 な ど 】


(邦 文)

  1. 久下裕司:特集 心臓病における核医学検査の進歩 循環器領域の放射性薬剤の進歩。呼吸と循環, 61(11): 1001-1007, 2013.

  2. 久下裕司、玉木長良:特集 心血管イメージング最前線-エコー, CTからcoronary imagingまで- 5.核医学検査 f. 分子イメージングの方向性。Heart View, 17 (12)(増刊号): 320-325, 2013.

  3. 久下裕司、玉木長良:特集 「百聞は一見にしかず 生体イメージングがもたらす診断と治療の戦略」 セミナー 循環器領域の分子イメージング。ファルマシア, 49(7): 682-687, 2013.

  4. 久下裕司、玉木長良:特集 不安定プラークの病態と診断 10.不安定プラークと分子イメージング。月刊循環器, 3(1): 69-77, 2013.

  5. 久下裕司:巻頭言 コンパニオン診断と分子イメージング。Isotope News,No.715:1, 2013年11月号




2012 年

【 著 書 】

  1. 久下裕司、玉木長良:E心臓核医学の展望。①循環器疾患および動脈硬化の分子イメージング。西村恒彦編集 BRAND NEW 心臓核医学。金原出版、東京、2012, pp248-254.

  2. 久保直樹:化学。福士政広編集、山内浩司・久保直樹・津田啓介・大谷浩樹・加藤真一著 第1種放射線取扱主任者試験重要問題集中トレーニング、メジカルビュー社、東京、2012, pp90-152.

  3. 久保直樹:第4章核医学検査技術学。オーム社編。2013年版診療放射線技師国家試験合格! Myテキスト。オーム社編集、オーム社、2012, pp141-189.

  4. 久保直樹:第4章放射化学、福士政広編集 診療放射線技師ポケット・レビュー帳2nd edition.メジカルビュー社、東京、2012, pp121-146.


【 英 文 論 文 な ど 】

  1. Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N: Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice. Biol Pharm Bull. 2012; 34 (12): 2214-2223.

  2. Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y: Quantitative Determination of Apoptosis of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus. J Nucl Med. 2012; 53(10):1585-91.

  3. Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y: Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma. Int J Oncol. 2012; 41(5): 1593-600.

  4. Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H: Norepinephrine Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated (2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine. Mol Imaging. 2012; 11(4): 280-5.

  5. Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G: Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012; 39: 1246-1253.

  6. Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, YamaguchiS, Houkin K, Tanaka S, Kuge Y, Tamaki N. 18F-Fluoromisonidazole positronemission tomography may differentiate glioblastoma multiforme from lessmalignant gliomas. Eur J Nucl Med Mol Imaging. 2012; 39(5): 760-70.

  7. Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N: Intracerebral, but not intravenous, transplantation of bone marrow stromal cells enhances functional recovery in rat cerebral infarct: An optical imaging study. Neuropathology. 2012; 32(3): 217-26.

  8. Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y, Tamaki N, Sasaki H: Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus. J Neurol Sci. 2012; 315(1-2): 55-9.

  9. Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y, Houkin K, Tamaki N, Iwasaki Y: Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats - In vivo cell tracking study by near infrared fluorescence imaging. Neurosurgery. 2012; 70(2): 435-44; discussion 444.

  10. Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H: A novel murine model for non-alcoholic steatohepatitis developedby combination of a high-fat diet and oxidized low-density lipoprotein.Lab Invest. 2012; 92(2): 265-81.

  11. Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N, Kuge Y: Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like Peptide 1. Ann Nucl Med. 2012; 26(2): 184-91.


【 総 説 な ど 】

  1. 久下裕司、趙 芫、趙 松吉、玉木長良: 特集1 心臓核医学の最先端 1.動脈硬化イメージング-実験的検討。PETジャーナル、18(Summer): 14-16, 2012.

  2. 久下裕司、西嶋剣一、孫田恵一、趙 松吉、玉木長良: 医薬品開発(又は創薬・育薬)における分子イメージング技術の現状と進歩。 医薬品医療機器レギュラトリーサイエンス、43 (4), 308-313, 2012.

  3. 玉木長良、吉永恵一郎、久下裕司: 交感神経と循環器疾患 交感神経イメージング。 Cardiac Practice, 23 (2): 143-147, 2012.

  4. 玉木長良、吉永恵一郎、久下裕司: 特集冠動脈疾患の診断・治療における画像診断の進歩 分子イメージングによる冠動脈病変評価、 Cardiac Practice, 23 (1): 23-27, 2012.

  5. 藤下稔雄、小浦哲、小玉亮一、井手口猛、久保直樹、越智誠:Emission dataとCTAC dataの位置ずれによる脳血流SPECT countsの変化。日本放射線技師会誌、 59(5):527-531, 2012.

  6. 久保直樹:フィルタ補正逆投影法・逐次近似法について、START, 48:13-15, 2012.

  7. 久保直樹:分子イメージング技術の向上のために-教育プログラムの構築と実践-。平成24年度放射線安全取扱部会年次大会要旨集、77-78, 2012.

  8. 久保直樹:核医学専門技師としての責務。北海道放射線技術雑誌、73:39-41, 2012.





2011 年

【 著 書 】

  1. 久下裕司、関興一:第9章 放射線と生体。9.1 身の回りの放射線とその生体への影響。佐治英郎 編集。NEW 放射化学・放射薬品学。廣川書店、東京、2011.

  2. 玉木長良、久下裕司:核医学検査。動脈硬化の内科治療に迫る、新・心臓病診療プラクティス16、吉川純一、笠貫宏、土師一夫、別府慎太郎、松崎益徳、(編集)、文光堂、2011, pp133-138.

  3. 久保直樹:第4章核医学検査技術学。オーム社編。診療放射線技師国家試験合格! Myテキスト。オーム社(編集)、オーム社、 2011, pp133-175.


【 英 文 論 文 な ど 】

  1. Hua Li, Songji Zhao, Yongnan Jin, Ken-ichi Nishijima, Hiromichi Akizawa, Kazue Ohkura, Nagara Tamaki, Yuji Kuge: A radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown. Nucl Med Comn. 2011; 32 (12): 1211-5.

  2. Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H: A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents. Mol Imaging Biol. 2011; 13 (6): 1196-1203

  3. Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H: PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol Imaging Biol. 2011; 13 (5): 1003-10.

  4. Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N: Dynamic (11)C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET. Eur J Nucl Med Mol Imaging. 2011; 38(10): 1876-86.

  5. Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Localization of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with Macrophage Infiltration but not Lipid Deposition in the Lesion. Mol Imaging Biol. 2011; 13(4): 712-20.

  6. Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y: Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain. Neurosurgery. 2011; 68(4): 1036-47; discussion 1047.

  7. Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H: 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncol Rep. 2011; 26: 725-730.

  8. Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa H, Shono Y, Saji H, Minematsu K, Tamaki N. Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model. Neurosci Lett. 2011; 495(3): 210-215.

  9. Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima K, Kuge Y, Tamaki N: Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions. Ann Nucl Med. 2011; 25(3): 213-20.

  10. Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N: Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging. Eur J Nucl Med Mol Imaging. 2011; 38(4): 742-52.

  11. Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M, Hirata K, Saji H, Tamaki N, Minematsu K: Gene expression associated with an enriched environment after transient focal ischemia. Brain Res. 2011; 1376: 60-65

  12. Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y, Tamaki N: Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment. Nucl Med Commun. 2011; 32(1): 63-70.

  13. Morimoto Y, Ueno Y, Takeuchi W, Kojima S, Matsuzaki K, Ishitsu T, Umegaki K, Kiyanagi Y, Kubo N, Katoh C, Shiga T, Shirato H, Tamaki N. Development of a 3D brain PET scanner using CdTe semiconductor detectors and its first clinical application. IEEE Trans Nucl Sci. 58(5):2181-2189, 2011



【 総 説 な ど 】

  1. 久下裕司、竹井俊樹、趙 松吉: 特集1 次世代腫瘍分子イメージング 4.アポトーシスイメージングプローブ。PETジャーナル、13(Spring): 23-25, 2011.

  2. 久下 裕司、西嶋剣一、趙 松吉: 特集1 核医学検査の新しい展開~治療戦略への応用 治療戦略に役立つ放射性薬剤の開発。映像情報メディカル、 43 (11), 842-849, 2011.




2010 年

【 編 書 】

  1. Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy and Drug Development. Springer (Springer Science+Business Media), Heidelberger, 2010.


【 著 書 】

  1. Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.

  2. Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.

  3. Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki N: Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.60-68.

  4. Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.69-77.

  5. Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders Perspective for Translational Research and Clinical Application. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.126-138.

  6. Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.

  7. 久下裕司、西嶋剣一、玉木長良:第18章 心臓核医学の分子イメージング 1.心筋交感神経・受容体イメージング。編集主幹:米倉義晴 編集委員:伊藤正敏、窪田和雄、佐治英郎、玉木長良、中川恵一、畑澤 順、間賀田泰寛、渡辺恭良、寺田弘司。臨床医とコメディカルのための最新クリニカルPET。先端医療技術研究所、東京、2010.

  8. 玉木長良、吉永恵一郎、久下裕司:第1章 心・血管病の分子イメージングの歴史、現状。今泉 勉、Jagat Narula監修、田原宣広編集。心・血管病の分子イメージング。永井書店、大阪、2010.


【 英 文 論 文 な ど 】

  1. Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3

  2. Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9

  3. Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H, Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. Br J Pharmacol. 2010; 159: 1201 - 1210.

  4. Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation and identification of new vasodilative substances in diesel exhaust particles. Environ Sci Pollut Res Int. 2010;17(3):717-23.

  5. Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.

  6. Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.

  7. Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono M, Saji H: Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.

  8. Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.

  9. Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med Mol Imaging. 2010;37(8):1566-1574.




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