Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N: Ferrous Ferric Chloride
Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection
in Mice. Biol Pharm Bull. 2012; 34 (12): 2214-2223.
Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss
HW, Blankenberg FG, Tamaki N, Kuge Y: Quantitative Determination of Apoptosis
of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus. J
Nucl Med. 2012; 53(10):1585-91.
Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi
M, Tamaki N, Kuge Y: Evaluation of changes in the tumor microenvironment
after sorafenib therapy by sequential histology and 18F-fluoromisonidazole
hypoxia imaging in renal cell carcinoma. Int J Oncol. 2012; 41(5): 1593-600.
Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H: Norepinephrine
Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated
(2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine. Mol Imaging. 2012; 11(4):
280-5.
Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki
N, Kimura G: Cardiac β-adrenergic receptor density and myocardial systolic
function in the remote noninfarcted region after prior myocardial infarction
with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012; 39:
1246-1253.
Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, YamaguchiS,
Houkin K, Tanaka S, Kuge Y, Tamaki N. 18F-Fluoromisonidazole positronemission
tomography may differentiate glioblastoma multiforme from lessmalignant
gliomas. Eur J Nucl Med Mol Imaging. 2012; 39(5): 760-70.
Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y,
Tamaki N: Intracerebral, but not intravenous, transplantation of bone marrow
stromal cells enhances functional recovery in rat cerebral infarct: An
optical imaging study. Neuropathology. 2012; 32(3): 217-26.
Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y,
Tamaki N, Sasaki H: Writing errors in ALS related to loss of neuronal integrity
in the anterior cingulate gyrus. J Neurol Sci. 2012; 315(1-2): 55-9.
Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y,
Houkin K, Tamaki N, Iwasaki Y: Therapeutic effects of intra-arterial delivery
of bone marrow stromal cells in traumatic brain injury of rats - In vivo
cell tracking study by near infrared fluorescence imaging. Neurosurgery.
2012; 70(2): 435-44; discussion 444.
Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki
N, Chiba H: A novel murine model for non-alcoholic steatohepatitis developedby
combination of a high-fat diet and oxidized low-density lipoprotein.Lab
Invest. 2012; 92(2): 265-81.
Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N,
Kuge Y: Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like
Peptide 1. Ann Nucl Med. 2012; 26(2): 184-91.
Hua Li, Songji Zhao, Yongnan Jin, Ken-ichi Nishijima, Hiromichi Akizawa,
Kazue Ohkura, Nagara Tamaki, Yuji Kuge: A radiolabeled uracil derivative
as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation
into tumor cells by target gene knockdown. Nucl Med Comn. 2011; 32 (12):
1211-5.
Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H: A Pre-targeting
Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based
Contrast Agents. Mol Imaging Biol. 2011; 13 (6): 1196-1203
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka
S, Kizaka-Kondoh S, Hiraoka M, Saji H: PET Imaging of Hypoxia-Inducible
Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable
Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol Imaging Biol.
2011; 13 (5): 1003-10.
Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa
M, Tamaki N: Dynamic (11)C-methionine PET analysis has an additional value
for differentiating malignant tumors from granulomas: an experimental study
using small animal PET. Eur J Nucl Med Mol Imaging. 2011; 38(10): 1876-86.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Localization
of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with
Macrophage Infiltration but not Lipid Deposition in the Lesion. Mol Imaging
Biol. 2011; 13(4): 712-20.
Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M,
Iwasaki Y: Near-infrared fluorescence labeling allows non-invasive tracking
of bone marrow stromal cells transplanted into rat infarct brain. Neurosurgery.
2011; 68(4): 1036-47; discussion 1047.
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y,
Kinoshita I, Tamaki N, Dosaka-Akita H: 18F-Fluorothymidine PET/CT as an
early predictor of tumor response to treatment with cetuximab in human
lung cancer xenografts. Oncol Rep. 2011; 26: 725-730.
Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa
H, Shono Y, Saji H, Minematsu K, Tamaki N. Gene and protein analysis of
brain derived neurotrophic factor expression in relation to neurological
recovery induced by an enriched environment in a rat stroke model. Neurosci
Lett. 2011; 495(3): 210-215.
Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima
K, Kuge Y, Tamaki N: Semiquantitative analysis of C-11 methionine PET may
distinguish brain tumor recurrence from radiation necrosis even in small
lesions. Ann Nucl Med. 2011; 25(3): 213-20.
Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N: Performance characterization
of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality
imaging. Eur J Nucl Med Mol Imaging. 2011; 38(4): 742-52.
Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M,
Hirata K, Saji H, Tamaki N, Minematsu K: Gene expression associated with
an enriched environment after transient focal ischemia. Brain Res. 2011;
1376: 60-65
Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y,
Tamaki N: Regional partition coefficient of water in patients with cerebrovascular
disease and its effect on rCBF assessment. Nucl Med Commun. 2011; 32(1):
63-70.
Morimoto Y, Ueno Y, Takeuchi W, Kojima S, Matsuzaki K, Ishitsu T, Umegaki
K, Kiyanagi Y, Kubo N, Katoh C, Shiga T, Shirato H, Tamaki N. Development
of a 3D brain PET scanner using CdTe semiconductor detectors and its first
clinical application. IEEE Trans Nucl Sci. 58(5):2181-2189, 2011
Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy
and Drug Development. Springer (Springer Science+Business Media), Heidelberger,
2010.
【 著 書 】
Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.
Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment
of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.
Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki
N: Initial Performance Measurement of an Integrated PET/SPECT/CT System
for Small Animal Imaging. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.60-68.
Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular
Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG
and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy
and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business
Media), Heidelberger, 2010, pp.69-77.
Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation
for Central Nervous System Disorders ?Perspective for Translational Research
and Clinical Application. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.126-138.
Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge
Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal
Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.
Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K,
Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine
phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme
imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3
Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection of membrane
type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting
method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9
Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H,
Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral
thalamic nucleus play an important role in anti-allodynic effects. Br J
Pharmacol. 2010; 159: 1201?1210.
Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation
and identification of new vasodilative substances in diesel exhaust particles.
Environ Sci Pollut Res Int. 2010;17(3):717-23.
Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New
NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.
Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound
for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono
M, Saji H: Tissue factor detection for selectively discriminating unstable
plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.
Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi
J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane
type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing
atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.
Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M,
Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible
factor-1-active tumours: pretargeted imaging with a protein degrading in
a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med
Mol Imaging. 2010;37(8):1566-1574.
Kuge Y: Chapter 11 Technetium-99m Annexin-A5 for Apoptosis Imaging. In:
Technetium-99m Radiopharmaceuticals: Status and Trends. IAEA RADIOISOTOPES
AND RADIOPHARMACEUTICALS SERIES No. 1. INTERNATIONAL ATOMIC ENERGY AGENCY.
VIENNA. 2009; 241-253.
【 英 文 論 文 な ど 】
Kuge Y, Obokata N , Kimura H, Katada Y, Temma T, Sugimoto Y, Aita K, Seki
K, Tamaki N, Saji H: Synthesis and evaluation of a radioiodinated Lumiracoxib
derivative for the imaging of cyclooxygenase-2 expression. Nucl Med Biol.
2009; 36(8): 869-876.
Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh
S, Hiraoka M, Saji H: Imaging of HIF-1-active tumor hypoxia using a protein
effectively delivered to and specifically stabilized in HIF-1-active tumor
cells. J Nucl Med. 2009; 50(6): 942-949.
Temma T, Sano K, Kuge Y, Kamihashi J, Takai N, Ogawa Y, Saji H: Development
of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase
on malignant tumors. Biol Pharm Bull. 2009; 32(7): 1272-1277.
Herrmann K, Takei T, Kanegae K, Shiga T, Buck AK, Altomonte J, Schwaiger
M, Schuster T, Nishijima K, Kuge Y, Tamaki N: Clinical Value and Limitations
of [(11)C]-Methionine PET for Detection and Localization of Suspected Parathyroid
Adenomas. Mol Imaging Biol. 2009; 11(5): 356-363. [Epub ahead of print]
Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada
S, Kuge Y, Tamaki N, Tsutsui H: Myocardial {beta}-Adrenergic Receptor Density
Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After
Carvedilol reatment in Patients with Idiopathic Dilated Cardiomyopathy.
J Nucl Med. 2009; 50(2): 220-225
Seki K, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation
and identification of new vasodilative substances in diesel exhaust particles.
Environ Sci Pollut Res Int. 2009 Jun 26. [Epub ahead of print]
【 総 説 な ど 】
Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging of Apoptosis with
Radio-Labeled Annexin A5 Focused on the Evaluation of Tumor Response to
Chemotherapy. Anti-Cancer Agents in Medicinal Chemistry. 2009; 9: 1003-1011.
Takahashi M, Seki K, Nishijima K, Zhao S, Kuge Y, Tamaki N, Ohkura K: Synthesis
of a radioiodinated thymidine phosphorylase inhibitor and its preliminary
evaluation as a potential SPECT tracer for angiogenic enzyme expression.
J Labelled Compounds and Radiopharmaceuticals. 2008; 51(11): 384-387.
Yimin, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki
N: Mutual modulation between interleukin-10 and interleukin-6 induced by
Rhodococcus aurantiacus infection in mice. Microbes Infect. 2008; 10(14-15):
1450-1458.
Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Prolonged
High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in
Apolipoprotein E-Deficient and Wild-Type C57BL/6J Mice. J Nucl Med. 2008;
49(10): 1707-1714.
Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Abe J, Takai N, Kamihashi J,Shiomi
M, Minami M, Kita T, Saji H: Targeting of lectinlike oxidized low-density
lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody:
potential agent for imaging of vulnerable plaque. J Nucl Med 2008; 49(10):
1677-1685
Takahashi M, Seki K, Nishijima K, Kuge Y, Tamaki N, Ohkura K: SYNTHESIS
OF 11C-LABELED URACIL DERIVATIVE FOR A PET TRACER TARGETING THYMIDINE PHOSPHORYLASE.
Heterocycles. 2008; 76(1): 237-241.
Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M,
Saji H: Prominent lectin-like oxidized LDL receptor-1 (LOX-1) expression
in atherosclerotic lesions is associated with tissue factor expression
and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull. 2008; 31(8):
1475-1482.
Temma T, Kuge Y, Sano K, Kamihashi J, Obokata N, Kawashima H, Magata Y,
Saji H: PET O-15 cerebral blood flow and metabolism after acute stroke
in spontaneously hypertensive rats. Brain Res. 2008; 1212: 18-24.
Wu YW, Naya M, Tsukamoto T, Komatsu H, Morita K, Yoshinaga K, Kuge Y, Tsutsui
H, Tamaki N: Heterogeneous Reduction of Myocardial Oxidative Metabolism
in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate
PET. Circ J. 2008; 72(5): 786-792.
Seki K, Aizawa K, Sugaoi T, Kimura M, Ohkura K: Synthesis of Highly Conjugated
Arylpropenylidene-1,3-Diazin-2-ones via Paterno-Buchi Reaction by Photoreaction
of 5-Fluoro-1,3-dimethyluracil with 1-Methoxynaphthalenes. Chemistry Letters.
2008; 37 (8): 872-873.
Noya Y, Mikami Y, Taneda S, Mori Y, Suzuki AK, Ohkura K, Yamaki K, Yoshino
S, Seki K: Improvement of an efficient separation method for chemicals
in diesel exhaust particles: analysis for nitrophenols. K ESPR (Environmental
Science and Pollution Research). 2008; 5 (4): 318-321.
Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki
K, Tamaki N: Usefulness of 11C-Methionine for Differentiating Tumors from
Granulomas in Experimental Rat Models: A Comparison with 18F-FDG and 18F-FLT.
J Nucl Med. 2008; 49(1): 135-141
Kiyono Y, Sugita T, Ueda M, Kawashima H, Kanegawa N, Kuge Y, Fujibayashi
Y, Saji H: Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine
as a radioligand for imaging of norepinephrine transporter in the heart.
Nucl Med Biol. 2008; 35(2): 213-218.