北海道大学アイソトープ総合センター
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アイソトープ総合センター業績集

　　　　　　　　　　　　　　　　2010年　　　　　2009年　　　　　2008年 　　　2007年

2010年

編著

  1. Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy and Drug Development. Springer (Springer Science+Business Media), Heidelberger, 2010.

著書

  1. Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.

  2. Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.

  3. Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki N: Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.60-68.

  4. Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.69-77.

  5. Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders ?Perspective for Translational Research and Clinical Application. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.126-138.

  6. Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.

  7. 久下裕司、西嶋剣一、玉木長良：第18章 心臓核医学の分子イメージング　1.心筋交感神経・受容体イメージング。編集主幹：米倉義晴　編集委員：伊藤正敏、窪田和雄、佐治英郎、玉木長良、中川恵一、畑澤　順、間賀田泰寛、渡辺恭良、寺田弘司。臨床医とコメディカルのための最新クリニカルPET。先端医療技術研究所、東京、2010

  8. 玉木長良、吉永恵一郎、久下裕司：第1章 心・血管病の分子イメージングの歴史、現状。今泉　勉、Jagat Narula監修、田原宣広編集。心・血管病の分子イメージング。永井書店、大阪、2010.

英文論文など

  1. Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3

  2. Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection　of　membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9

  3. Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H, Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. Br J Pharmacol. 2010; 159: 1201?1210.

  4. Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation and identification of new vasodilative substances in diesel exhaust particles. Environ Sci Pollut Res Int. 2010;17(3):717-23.

  5. Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.

  6. Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.

  7. Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono M, Saji H: Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.

  8. Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.

  9. Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med Mol Imaging. 2010;37(8):1566-1574.


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2009年

著書

  1. Kuge Y: Chapter 11 Technetium-99m Annexin-A5 for Apoptosis Imaging. In: 　Technetium-99m Radiopharmaceuticals: Status and Trends. IAEA RADIOISOTOPES AND RADIOPHARMACEUTICALS SERIES No. 1. INTERNATIONAL ATOMIC ENERGY AGENCY. VIENNA. 2009; 241-253.

英文論文など

  1. Kuge Y, Obokata N , Kimura H, Katada Y, Temma T, Sugimoto Y, Aita K, Seki K, Tamaki N, Saji H: Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. Nucl Med Biol. 2009; 36(8): 869-876. 　


  2. Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S, Hiraoka M, Saji H: Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells. J Nucl Med. 2009; 50(6): 942-949.


  3. Temma T, Sano K, Kuge Y, Kamihashi J, Takai N, Ogawa Y, Saji H: Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors. Biol Pharm Bull. 2009; 32(7): 1272-1277.


  4. Herrmann K, Takei T, Kanegae K, Shiga T, Buck AK, Altomonte J, Schwaiger M, Schuster T, Nishijima K, Kuge Y, Tamaki N: Clinical Value and Limitations of [(11)C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas. Mol Imaging Biol. 2009; 11(5): 356-363. [Epub ahead of print]


  5. Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada S, Kuge Y, Tamaki N, Tsutsui H: Myocardial {beta}-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol reatment in Patients with Idiopathic Dilated Cardiomyopathy. J Nucl Med. 2009; 50(2): 220-225


  6. Seki K, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation and identification of new vasodilative substances in diesel exhaust particles. Environ Sci Pollut Res Int. 2009 Jun 26. [Epub ahead of print]


総説など

  1. Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging of Apoptosis with Radio-Labeled Annexin A5 Focused on the Evaluation of Tumor Response to Chemotherapy. Anti-Cancer Agents in Medicinal Chemistry. 2009; 9: 1003-1011.


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2008年


英文論文など


  1. Takahashi M, Seki K, Nishijima K, Zhao S, Kuge Y, Tamaki N, Ohkura K: Synthesis of a radioiodinated thymidine phosphorylase inhibitor and its preliminary evaluation as a potential SPECT tracer for angiogenic enzyme expression. J Labelled Compounds and Radiopharmaceuticals. 2008; 51(11): 384-387.


  2. Yimin, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N: Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice. Microbes Infect. 2008; 10(14-15): 1450-1458.


  3. Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type C57BL/6J Mice. J Nucl Med. 2008; 49(10): 1707-1714.


  4. Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Abe J, Takai N, Kamihashi J,Shiomi M, Minami M, Kita T, Saji H: Ｔargeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque. J Nucl Med 2008; 49(10): 1677-1685


  5. Takahashi M, Seki K, Nishijima K, Kuge Y, Tamaki N, Ohkura K: SYNTHESIS OF 11C-LABELED URACIL DERIVATIVE FOR A PET TRACER TARGETING THYMIDINE PHOSPHORYLASE. Heterocycles. 2008; 76(1): 237-241.


  6. Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M, Saji H: Prominent lectin-like oxidized LDL receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull. 2008; 31(8): 1475-1482.


  7. Temma T, Kuge Y, Sano K, Kamihashi J, Obokata N, Kawashima H, Magata Y, Saji H: PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats. Brain Res. 2008; 1212: 18-24.


  8. Wu YW, Naya M, Tsukamoto T, Komatsu H, Morita K, Yoshinaga K, Kuge Y, Tsutsui H, Tamaki N: Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET. Circ J. 2008; 72(5): 786-792.


  9. Seki K, Aizawa K, Sugaoi T, Kimura M, Ohkura K: Synthesis of Highly Conjugated Arylpropenylidene-1,3-Diazin-2-ones via Paterno-Buchi Reaction by Photoreaction of 5-Fluoro-1,3-dimethyluracil with 1-Methoxynaphthalenes. Chemistry Letters. 2008; 37 (8): 872-873.


  10. Noya Y, Mikami Y, Taneda S, Mori Y, Suzuki　ＡＫ, Ohkura K, Yamaki K, Yoshino S, Seki K: Improvement of an efficient separation method for chemicals in diesel exhaust particles: analysis for nitrophenols. K ESPR (Environmental Science and Pollution Research). 2008; 5 (4): 318-321.


  11. Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki K, Tamaki N: Usefulness of 11C-Methionine for Differentiating Tumors from Granulomas in Experimental Rat Models: A Comparison with 18F-FDG and 18F-FLT. J Nucl Med. 2008; 49(1): 135-141


  12. Kiyono Y, Sugita T, Ueda M, Kawashima H, Kanegawa N, Kuge Y, Fujibayashi Y, Saji H: Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart. Nucl Med Biol. 2008; 35(2): 213-218.


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2007年


英文論文など


  1. Tsukamoto T, Morita K, Naya M, Inubushi M, Katoh C, Nishijima K, Kuge Y, Okamoto H, Tsutsui H, Tamaki N: Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. J Nucl Med. 2007; 48(11): 1777-1782.


  2. Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M: All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J Immunology. 2007; 179(7): 4616-4625.


  3. Zhao S, Kuge Y, Kohanawa M, Takahashi T, Kawashima H, Temma T, Takei T, Zhao Y, Seki K, Nagara T: Extensive 18F-FDG Uptake and Its Modification with Corticosteroid in a Granuloma Rat Model: An Experimental Study for Differentiating Granuloma from Tumors. Eur J Nucl Med Mol Imaging. 2007; 34(12): 2096-2105.


  4. Aita K, Temma T, Kuge Y, Saji H: Development of Novel Neodymium Compound for In Vivo Fluorescence Imaging. Luminescence. 2007; 22(5): 455-461.


  5. Zhao Y, Kuge Y, Zhao S, Morita K, Inubushi M, Strauss HW, Blankenberg FG, Tamaki N: Comparison of 99mTc-annexin A5 with 18F-FDG for detection of atherosclerosis in ApoE-/- mice. Eur J Nucl Med Mol Imaging. 2007; 34(11): 1747-1755.


  6. Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H: Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability--analysis in hypercholesterolemic rabbits. Atherosclerosis. 2007; 195(1): 48-56.


  7. Ohkura K, Sugaoi T, Takahashi T, Seki K: Diastereodifferentiating [4+2]-photocycloaddition of tegafur with naphthalene. Heterocycles, 72, 2007; 691-695.


  8. Kuge Y, Takai N, Ishino S, Temma T, Shiomi M, Saji H: Expression Profiles of MT1-MMP, MMP-2 and COX-2 in Rabbit Atherosclerosis: Comparison with Plaque Instability Analysis. Biol Pharm Bull. 2007; 30(9): 1634-1640.


  9. Kanegae K, Nakano I, Kimura K, Kaji H, Kuge Y, Shiga T, Zhao S, Okamoto S, Tamaki N: Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis. Ann Nucl Med. 2007; 21(6): 331-337.


  10. Kiyono Y, Kuge Y, Katada Y, Kawashima H, Magata Y, Saji H: Applicability of a high-resolution small semiconductor gamma camera to small animal imaging. Nucl Med Commun. 2007; 28(9): 736-741.


  11. Ishino S, Kuge Y, Takai N, Tamaki N, Strauss HW, Blankenberg FG, Shiomi M, Saji H: 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. Eur J Nucl Med Mol Imaging. 2007; 34(6): 889-899.


  12. Kiyono Y, Yamashita T, Kuge Y, Katsura T, Inui K, Saji H: Is MIBG a Substrate of P-glycoprotein? Eur J Nucl Med Mol Imaging. 2007; 34(4): 448-452.


  13. Seki K, Nishijima K, Kuge Y, Tamaki N, Wiebe LI, Ohkura K: A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy. J Pharm Pharmaceut Sci. 2007; 10(2): 212-216.
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2006年


英文論文など


  1. Ohkura K, Yamaguchi T, Nishijima K, Kuge Y, Seki K: Photochemical synthesis of polycyclic pyrimidines through the acid catalyzed cycloaddition of 6-chloro-1-methyluracil to methyl substituted bezenes. Heterocycles. 2006; 70: 501-508.


  2. Morita K, Tsukamoto T, Naya M, Noriyasu K, Inubushi M, Shiga T, Katoh C, Kuge Y, Tsutsui H, Tamaki N: Smoking Cessation Normalizes Coronary Endothelial Vasomotor Response Assessed with 15O-Water and PET in Healthy Young Smokers. J Nucl Med. 2006; 47(12): 1914-1920.


  3. Temma T, Magata Y, Kuge Y, Shimonaka S, Sano K, Katada Y, Kawashima H, Mukai T, Watabe H, Iida H, Saji H: Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable 15O-O2. J Cereb Blood Flow Metab. 2006; 26: 1577-1583.


  4. Tsukamoto T, Morita K, Naya M, Katoh C, Inubushi M, Kuge Y, Tsutsui H, Tamaki N: Myocardial flow reserve is influenced by both coronary artery stenosis severity and coronary risk factors in patients with suspected coronary artery disease. Eur J Nucl Med Mol Imaging. 2006; 33: 1150-1156.


  5. Ohkura K, Nishijima K, Sanoki K, Kuge Y, Nagara T, Seki K: A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene. Tetrahedron Letters. 2006; 47: 5321- 5323.


  6. Shiga T, Ikoma K, Katoh C, Isoyama H, Matsuyama T, Kuge Y, Kageyama H, Kohno T, Terae S, Tamaki N: Loss of neuronal integrity: a cause of hypometabolism in patients with traumatic brain injury without MRI abnormality in the chronic stage. Eur J Nucl Med Mol Imaging. 2006; 33(7): 817-822.


  7. Ohkura K, Ishihara T, Diakur JM, Seki K: Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes. Heterocycles. 2006; 69: 515-520.


  8. Kanegawa N, Kiyono Y, Kimura H, Sugita T, Kajiyama S, Kawashima H, Ueda M, Kuge Y, Saji H: Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl) morpholine for imaging brain norepinephrine transporter. Eur J Nucl Med Mol Imaging. 2006; 33(6): 639-647.


  9. Ogawa M, Iida Y, Nakagawa M, Kuge Y, Kawashima H, Tominaga A, Ueda M, Magata Y, Saji H: Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer's disease. Nucl Med Biol. 2006; 33(2): 249-254.


  10. Kuge Y, Katada Y, Shimonaka S, Temma T, Kimura H, Kiyono Y, Yokota C, Minematsu K, Seki K, Tamaki N, Ohkura K, Saji H: Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression. Nucl Med Biol. 2006; 33(1): 21-27.

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