| (1) |
Development
of early and rapid diagnostic methods:
IgM ELISA, immuno-PCR, and DNA array will be developed as rapid
and early diagnosis of each zoonosis and the sensitivities and
specificities will be evaluated. Highly sensitive diagnostic
method of prion disease will be developed for live animals.
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| (2) |
Development
of vaccines:
Vaccines for each zoonosis will be developed and evaluated.
The most appropriate vaccine for each zoonosis will be selected
from the mucosal vaccines, replication incompetent virus vaccines,
peptide vaccines, and DNA vaccines. |
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| (3) |
Epidemiological
investigations:
Positive areas for each zoonoses will be specified by sero-epidemiological
survey of animal and human sera. Pathogens will be isolated
from the samples collected from domestic animals, wild animals,
mosquitoes and ticks. From these data, the transmission
cycles and perpetuation mechanisms of the pathogens will be
revealed. International surveillance system will be constructed
and epidemiological information will be obtained through this
system. The information together with those collected
in the center will be opened for public. |
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| (4) |
Risk
analysis:
According to epidemiological information, risk analysis for each zoonosis
will be performed. The prediction of outbreaks, prevention of the
epidemic and eradication measure will be taken for zoonoses in Japan. For
zoonoses which may invade from abroad, the following preventive measures
will be taken; estimations for risks of invasion and the route, and risk
management system including the prevention of the invasion and the epidemic. |
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| (5) |
Genetic characterization of pathogens:
Genes of pathogens will be sequenced and phylogenetically
analyzed. From the data, the evolutions and origins of
the pathogens will be estimated. |
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| (6) |
Pathogenesis:
Molecular basis of pathogenesis of each of the pathogens will
be analyzed using animal models. In particular, the pathogenesis
of encephalitis and encephalopathy will be examined in West
Nile fever, tick-borne encephalitis, and influenza. That
of hemorrhagic manifestation and renal failure will be studied
in hantavirus infection. |
Educational Plan