Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge
Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N: Semiconductor
Detector-Based Scanners for Nuclear Medicine. In: Perspectives on Nuclear
Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;51-65.
Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y: Development
of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography
Probe. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and
Integrated Therapy. Springer Japan.2016;113-124.
Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N,
Kuge Y: Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe,
[123I]IIMU, for Translational Research. In: Perspectives on Nuclear Medicine
for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 125-130.
Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S,
Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki
N, Kuge Y: Discovery and Evaluation of Biomarkers for Atherosclerosis.
In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated
Therapy. Springer Japan.2016; 131-139.
Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S,
Tamaki N, Kuge Y: Radioimmunodetection of Atherosclerotic Lesions Focusing
on the Accumulation Mechanism of Immunoglobulin G. In: Perspectives on
Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer
Japan.2016; 141-150.
【 Papers 】
Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki
N, Higashikawa K, Yasui H, Kuge Y: Dynamic PET evaluation of elevated FLT
level after sorafenib treatment in mice bearing human renal cell carcinoma
xenograft. EJNMMI Res. 2016; 6(1): 90.
Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima K, Magota
K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: The reoxygenation
of hypoxia and the reduction of glucose metabolism in head and neck cancer
by fractionated radiotherapy with intensity-modulated radiation therapy.
Eur J Nucl Med Mol Imaging. 2016; 43(12): 2147-2154.
Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y: Optimization of helical
acquisition parameters to preserve uniformity of mouse whole body using
multipinhole collimator in single-photon emission computed tomography.
Results in Physics. 2016; 6: 659-663.
Masaki Y, Shimizu Y, Yoshioka T, Feng F, Zhao S, Higashino K, Numata Y,
Kuge Y: Imaging Mass Spectrometry Revealed the Accumulation Characteristics
of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia.
PLoS One. 2016; 11(8): e0161639.
Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura
K, Ken-Ichi N, Tamaki N, Kuge Y: The Thymidine Phosphorylase Imaging Agent
123I-IIMU Predicts the Efficacy of Capecitabine. J Nucl Med. 2016; 57(8):
1276-81.
Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R,
Nakanishi H, Ozeki E, Kuge Y, Saji H. Continuous-Flow Synthesis of N-Succinimidyl
4-[18F]fluorobenzoate Using a Single Microfluidic Chip. PLoS One. 2016;
11(7) :e0159303.
Toyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi
K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N: 18F-fluoromisonidazole
positron emission tomography can predict pathological necrosis of brain
tumors. Eur J Nucl Med Mol Imaging. 2016 Jul;43(8):1469-76.
Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka
T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge
Y: Characterization of the role of sphingomyelin synthase 2 in glucose
metabolism in whole-body and peripheral tissues in mice. Biochim Biophys
Acta. 2016; 1861(8 Pt A): 688-702.
Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y,
Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y: Imaging mass spectrometry
reveals acyl-chain- and region-specific sphingolipid metabolism in the
kidneys of sphingomyelin synthase 2-deficient mice. PLoS One. 2016; 11(3):
e0152191.
Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M: Regulatory
effect of interleukin-4 in the innate inflammatory response to Rhodococcus
aurantiacus infection in mice. J Interferon Cytokine Res. 35(3): 222-231,
2015.
Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi
H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki
N: Oli-godendroglial component complicates the prediction of tumour grading
with metabolic imaging. Eur J Nucl Med Mol Imaging. 42(6): 896-904, 2015
Kobayashi K, Hirata K, Yamaguchi S, Manabe O, Terasaka S, Kobayashi H,
Shiga T, Hattori N, Tanaka S, Kuge Y, Tamaki N: Prognostic value of volume-based
measurements on (11)C-methionine PET in glioma patients. Eur J Nucl Med
Mol Imaging. 42(7): 1071-1080, 2015
Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki
N, Kuge Y: Relationship between biodistribution of a novel thymidine phosphorylase
(TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med.
29(7): 582-587, 2015
Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge
Y: Combined plasma and tissue proteomic study of atherogenic model mouse:
approach to eucidate mlecular dterminants in aherosclerosis dvelopment.
J Proteome Res. 14(10): 4257-4269, 2015
Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino
K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y: The accumulation
mechanism of the hypoxia imaging probe "FMISO" by imaging mass
spectrometry: possible involvement of low-molecular metabolites. Sci Rep.
2015; 5:16802
Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino H,
Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y: Histological analyses
by matrix-assisted laser desorption/ionization-imaging mass spectrometry
reveal differential localization of sphingomyelin molecular species regulated
by particular ceramide synthase in mouse brains. Biochim Biophys Acta.
2015; 1851(12): 1554-65.
Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki
E, Kuge Y, Saji H: Application of Microreactor to the Preparation of C-11-Labeled
Compounds via O-[(11)C]Methylation with [(11)C]CH3I: Rapid Synthesis of
[(11)C]Raclopride. Chem Pharm Bull (Tokyo). 2015; 63(9): 737-40.
Yamaguchi A, Hanaoka H, Fujisawa Y, Zhao S, Suzue K, Morita A, Tominaga
H, Higuchi T, Hisaeda H, Tsushima Y, Kuge Y, Iida Y: Differentiation of
malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine
positron emission tomography. EJNMMI Res. 2015; 5: 29
Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K,
Tamaki N, Takeda H, Kuge Y: Radiolabeled BMIPP for imaging hepatic fatty
acid metabolism: Evaluation of hepatic distribution and metabolism in mice
at various metabolic status induced by fasting in comparison with palmitic
acid. Mol Imaging. 2015; 14(0): 1-11.
Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo
N, Ukon N, Nakano T, Tamaki N, Kuge Y: Irbesartan attenuates atherosclerosis
in Watanabe Heritable Hyperlipidemic rabbits: Noninvasive imaging of inflammation
by 18F-FDG PET. Mol Imaging. 2015; 14(0): 1-8
Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C,
Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada
Y: Increased metabolite levels of glycolysis and pentose phosphate pathway
in rabbit atherosclerotic arteries and hypoxic macrophage. PLOS One. 2014;
9(1): e86426.
Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida
T, Takemoto H, Tamaki N, Kuge Y: Suppressive effects of irbesartan on inflammation
and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging
with 14C-FDG and 99mTc-annexin A5. PLOS One. 2014; 9(2): e89338.
Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada
T, Horiguchi M, Hatate C, Kuge Y, Miwa S: A simple and rapid method for
standard preparation of gas phase extract of cigarette smoke. PLOS ONE.
2014; 9(9): e107856.
Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga
T, Kuge Y, Tamaki N：Evaluation of delineation of image details in semiconductor
PET utilizing the normalized mutual information technique；Nuclear Medicine
Communications . 2014; 35(6): 677-682.
Fatema CN, Zhao S, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge
Y: Dual tracer evaluation of dynamic changes in intratumoral hypoxic and
proliferative states after radiotherapy of human head and neck cancer zerografts
using radiolabaled FMISO and FLT. BMC Cancer. 2014; 14(1): 692.
Oshima N, Akizawa H, Zhao S, Nishijima K, Kitamura Y, Arano Y, Kuge Y,
Ohkura K: Design, synthesis and biological evaluation of negatively charged
111In-DTPA-octreotide derivatives. Bioorgan Med Chem. 2014; 22(4): 1377-1382.
Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki
N: Collimator for variable sensitivity and spatial resolution without the
need for exchange. IEEE Trans Nucl Sci. 2014; 61(5): 2489-2493.
Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H:
In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel
Activatable Near-Infrared Fluorescence Probe. Cancer Science. 2014; 105:
1056-62.
Onoe S, Temma T, Shimizu Y, Ono M, Saji H: Investigation of cyanine dyes
for in vivo optical imaging of altered mitochondrial membrane potential
in tumors. Cancer Medicine. 2014; 3: 775-86.
Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji
H: Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging
of Cancer Biomolecules. Nanomedicine: Nanotechnology, Biology and Medicine.
2014; 10: 187-95.
Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki
N, Kuroda S: 123I-Iomazenil Single Photon Emission Computed Tomography
Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy
in Rat Infarct Brain. Stroke. 2013; 44(10): 2869-74.
Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita H, Iwakiri T, Koshimoto
C, Kawai K, Tamaki N, Kuge Y, Asada Y. 18F-FDG uptake reflects thrombus
formation and tissue factor expression via nuclear factor-κB in rabbit
atherosclerotic lesions. Circ J. 2013; 77(10): 2626-35.
Zhao Y, Zhao S, Kuge Y, Tamaki N: Elevated 18F-FDG levels in blood and
organs following angiotensin II receptor blocker administration: Experiment
in mice administered telmisartan. J Nucl Med. 2013; 54(8): 1384-8.
Murakami M, Zhao S, Zhao Y, Fatema CN, Yu W, Nishijima K, Takiguchi M,
Tamaki N, Kuge Y: Increased intratumoral fluorothymidine (FLT) uptake level
after multikinase inhibitor sorafenib treatment in a human renal cell carcinoma
xenograft. Oncol Lett. 2013; 6(3): 667-672.
Noya Y, Seki KI, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate
C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S: Identification of stable
cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological
characterization of their cytotoxicity. Toxicology. 2013; 314(1): 1-10.
Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Akita H,
Tamaki N: Assessment of early changes in 3H-fluorothymidine uptake after
treatment with gefitinib in human tumor xenograft in comparison with Ki-67
and phospho-EGFR expression. BMC Cancer 2013; 13(1): 525.
Yi M, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N: Contribution
of Toll-Like Receptor 2 to the Response against Staphylococcus aureus Infection
in Mice. PloS One. 2013; 8 (9): e74287.
Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura
H, Fujii H, Inanami O. Radiation-induced nitric oxide mitigates tumor hypoxia
and radioresistance in a murine SCCVII tumor model. Biochem Biophys Res
Commun. 2013; 437(3): 420-425.
Sato J, Kitagawa Y, Yamazaki Y, Hata H, Okamoto S, Shiga T, Shindoh M,
Kuge Y, Tamaki N: 18F-Fluoromisonidazole PET Uptake Is Correlated with
Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma.
J Nucl Med. 2013; 54(7): 1060-5.
Kawai T, Kawashima H, Kuge Y, Saji H: Synthesis and evaluation of 11C-labeled
naphthalene derivative as a novel non-peptidergic probe for the β-secretase
(BACE1) imaging in Alzheimer's disease brain. Nucl Med Biol. 2013; 40(5):
705-9.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Attenuation
of apotosis by telmisartan in atherosclerotic plaques of apoE-/- mice:
evaluation using 99mTc-annexin A5. Mol Imaging. 2013; 12(5): 300-9.
Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa
Y, Kuge Y: Monitoring tumor proliferative response to radiotherapy using
18F-fluorothymidine in human head and neck cancer xenograft in comparison
with Ki-67. Ann Nucl Med. 2013; 27(4): 355-62.
Oashi K, Furukawa H, Nishihara H, Ozaki M, Oyama A, Funayama E, Hayashi
T, Kuge Y, Yamamoto Y: Pathophysiological Characteristics of Melanoma In-Transit
Metastasis in a Lymphedema Mouse Model. J Invest Dermatol. 2013; 133(2):
537-44
Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato
H, Tamaki N: High Reproducibility of Tumor Hypoxia Evaluated by 18F-Fluoromisonidazole
PET for Head and Neck Cancer. J Nucl Med. 2013; 54(2): 201-7.
Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki
N Kuge Y: Biological characteristics of intratumoral [F-18]fluoromisonidazole
distribution in a rodent model of glioma. Int J Oncol. 2013; 42(3): 823-30.
Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N:
Timing and cell dose determine therapeutic effects of bone marrow stromal
cell transplantation in rat model of cerebral infarct. Neuropathology.
2013; 33(2): 140-8.
Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R,
Takeuchi W, Kuge Y, Tamaki N, Shirato H: [(18)F]fluoromisonidazole and
a New PET System With Semiconductor Detectors and a Depth of Interaction
System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer.
Int J Radiat Oncol Biol Phys. 2013; 85(1): 142-7
Miyamoto M, Kuroda S, Zhao S, Magota K, Maruichi K, Ito M, Kawabori M,
Shichinohe H, Houkin K, Kuge Y, Tamaki N. Bone Marrow Stromal Cells Transplantation
Enhances Recovery of Local Glucose Metabolism after Cerebral Infarct in
Rats: A Serial 18F-FDG PET Study. J Nucl Med. 2013; 54(1): 145-50.
Suzuki A, Takeuchi W, Ishitsu T, Tsuchiya K, Morimoto Y, Ueno Y, Kobashi
K, Kubo N, Shiga T, Tamaki N: High-sensitivity brain SPECT system using
cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator.
Phys Med Biol. 2013;58(21):7715-31.
Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, Ono M, Saji
H.Miniaturized Antibodies for Imaging Membrane Type-1 Matrix Metalloproteinase
in CancersCancer Sci. 104(4):495-501 (2013)．
Kuge Y, Tamaki N: E Prospect of Nuclear Cardiology, ① Molecular Imaging
of Cardiovascular Diseases and Atherosclerosis (Nishimura T, ed.), BRAND
NEW Nuclear Cardiology, Kanehara & Co., Ltd., Tokyo, 2012, pp. 248-254
(in Japanese).
Yamauchi H, Kubo N, Tsuda K, Otani H, Kato S: Intensive Training of Important
Problems in Type-I Radiation Protection Supervisor’s Examination (Fukushi
M, ed.), Medical View Co., Ltd., Tokyo, 2012, pp. 90-152 (in Japanese).
Kubo N: Chap. 4 Nuclear Medicine Examination Techniques, My Text to Pass
National Examination of Radiological Technologists, 2013 (Ohmsha, Ltd.,
ed.), Ohmsha, Ltd., 2012, pp. 141-189 (in Japanese).
Kubo N: Chap. 4 Radiochemistry, (Fukushi M, ed.), Pocket Review for Radiological
Technologists, 2nd edition, Medical View Co., Ltd., Tokyo, 2012, pp. 121-146
(in Japanese).
【 Papers 】
Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N: Ferrous Ferric Chloride
Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection
in Mice. Biol Pharm Bull. 2012; 34 (12): 2214-2223.
Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss
HW, Blankenberg FG, Tamaki N, Kuge Y: Quantitative Determination of Apoptosis
of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus. J
Nucl Med. 2012; 53(10):1585-91.
Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi
M, Tamaki N, Kuge Y: Evaluation of changes in the tumor microenvironment
after sorafenib therapy by sequential histology and 18F-fluoromisonidazole
hypoxia imaging in renal cell carcinoma. Int J Oncol. 2012; 41(5): 1593-600.
Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H: Norepinephrine
Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated
(2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine. Mol Imaging. 2012; 11(4):
280-5.
Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki
N, Kimura G: Cardiac β-adrenergic receptor density and myocardial systolic
function in the remote noninfarcted region after prior myocardial infarction
with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012; 39:
1246-1253.
Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, YamaguchiS,
Houkin K, Tanaka S, Kuge Y, Tamaki N. 18F-Fluoromisonidazole positronemission
tomography may differentiate glioblastoma multiforme from lessmalignant
gliomas. Eur J Nucl Med Mol Imaging. 2012; 39(5): 760-70.
Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y,
Tamaki N: Intracerebral, but not intravenous, transplantation of bone marrow
stromal cells enhances functional recovery in rat cerebral infarct: An
optical imaging study. Neuropathology. 2012; 32(3): 217-26.
Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y,
Tamaki N, Sasaki H: Writing errors in ALS related to loss of neuronal integrity
in the anterior cingulate gyrus. J Neurol Sci. 2012; 315(1-2): 55-9.
Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y,
Houkin K, Tamaki N, Iwasaki Y: Therapeutic effects of intra-arterial delivery
of bone marrow stromal cells in traumatic brain injury of rats - In vivo
cell tracking study by near infrared fluorescence imaging. Neurosurgery.
2012; 70(2): 435-44; discussion 444.
Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki
N, Chiba H: A novel murine model for non-alcoholic steatohepatitis developedby
combination of a high-fat diet and oxidized low-density lipoprotein.Lab
Invest. 2012; 92(2): 265-81.
Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N,
Kuge Y: Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like
Peptide 1. Ann Nucl Med. 2012; 26(2): 184-91.
【 Review Articles, etc. 】
Kuge Y, Zhao Y, Zhao S, Tamaki N: Feature 1 Latest Nuclear Cardiology,
1. Imaging of Atherosclerosis - Experimental Examination -. PET Journal.
18(Summer): 14-16, 2012 (in Japanese).
Kuge Y, Nishijima K, Magota K, Zhao S, Tamaki N: Current Status and Progress
of Molecular Imaging in Drug Development. Pharmaceutical and Medical Device
Regulatory Science Society of Japan. 43(4): 308-313, 2012 (in Japanese).
Tamaki N, Yoshinaga K, Kuge Y: Sympathetic Nerve and Cardiovascular Diseases,
Imaging of Sympathetic Nerve. Cardiac Practice. 23(2): 143-147, 2012 (in
Japanese).
Tamaki N, Yoshinaga K, Kuge Y: Advances in Diagnostic Imaging for Diagnosis
and Treatment of Coronary Arterial Diseases, Evaluation of Coronary Lesions
by Molecular Imaging. Cardiac Practice. 23(1): 23-27, 2012 (in Japanese).
Fujishita T, Koura S, Kodama R, Ideguchi T, Kubo N, Ochi M: Misregistration
of CT Attenuation-Corrected Cerebral Blood Flow SPECT Images: Impact on
SPECT Counts. Japanese Journal of The Japan Association of Radiological
Technologists. 59(5): 527-531, 2012 (in Japanese).
Kubo N: Filter Back Projection and Successive Approximation. START. 48:
13-15, 2012 (in Japanese).
Kubo N: To Improve the Molecular Imaging Techniques - Establishment and
Practice of Educational Programs -. Collection of Abstracts of 2012 Annual
Meeting on Safe Handling of Radiation by the Japan Radioisotope Association.
77-78, 2012 (in Japanese).
Kubo N: Responsibility of Nuclear Medicine Specialist. Japanese Journal
of Hokkaido Association of Radiological Technologists. 73: 39-41, 2012
(in Japanese).
Kuge Y, Seki K: Chap. 9 Radiation and Living Organisms, 9.1 Effect of Ambient
Radiation on Living Organisms, (Saji H, ed.), NEW Radiochemistry/Radiopharmaceutics,
Hirokawa Shoten Co., Tokyo, 2011 (in Japanese).
Tamaki N, Kuge Y: Nuclear Medicine Examination, Internal Therapy for Atherosclerosis,
New Diagnostic Practice for Heart Disease 16 (Yoshikawa J, Kasanuki H,
Haji K, Beppu S, Matsuzaki M, eds.), Bunkodo Co., Ltd., 2011, pp. 133-138
(in Japanese).
Kubo N: Chap. 4 Nuclear Medicine Examination Techniques, My Text to Pass
National Examination of Radiological Technologists (Ohmsha, Ltd., ed.),
Ohmsha, Ltd., 2011, pp. 133-175 (in Japanese).
【 Papers 】
Hua Li, Songji Zhao, Yongnan Jin, Ken-ichi Nishijima, Hiromichi Akizawa,
Kazue Ohkura, Nagara Tamaki, Yuji Kuge: A radiolabeled uracil derivative
as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation
into tumor cells by target gene knockdown. Nucl Med Comn. 2011; 32 (12):
1211-5.
Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H: A Pre-targeting
Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based
Contrast Agents. Mol Imaging Biol. 2011; 13 (6): 1196-1203
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka
S, Kizaka-Kondoh S, Hiraoka M, Saji H: PET Imaging of Hypoxia-Inducible
Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable
Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol Imaging Biol.
2011; 13 (5): 1003-10.
Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa
M, Tamaki N: Dynamic (11)C-methionine PET analysis has an additional value
for differentiating malignant tumors from granulomas: an experimental study
using small animal PET. Eur J Nucl Med Mol Imaging. 2011; 38(10): 1876-86.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Localization
of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with
Macrophage Infiltration but not Lipid Deposition in the Lesion. Mol Imaging
Biol. 2011; 13(4): 712-20.
Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M,
Iwasaki Y: Near-infrared fluorescence labeling allows non-invasive tracking
of bone marrow stromal cells transplanted into rat infarct brain. Neurosurgery.
2011; 68(4): 1036-47; discussion 1047.
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y,
Kinoshita I, Tamaki N, Dosaka-Akita H: 18F-Fluorothymidine PET/CT as an
early predictor of tumor response to treatment with cetuximab in human
lung cancer xenografts. Oncol Rep. 2011; 26: 725-730.
Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa
H, Shono Y, Saji H, Minematsu K, Tamaki N. Gene and protein analysis of
brain derived neurotrophic factor expression in relation to neurological
recovery induced by an enriched environment in a rat stroke model. Neurosci
Lett. 2011; 495(3): 210-215.
Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima
K, Kuge Y, Tamaki N: Semiquantitative analysis of C-11 methionine PET may
distinguish brain tumor recurrence from radiation necrosis even in small
lesions. Ann Nucl Med. 2011; 25(3): 213-20.
Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N: Performance characterization
of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality
imaging. Eur J Nucl Med Mol Imaging. 2011; 38(4): 742-52.
Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M,
Hirata K, Saji H, Tamaki N, Minematsu K: Gene expression associated with
an enriched environment after transient focal ischemia. Brain Res. 2011;
1376: 60-65
Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y,
Tamaki N: Regional partition coefficient of water in patients with cerebrovascular
disease and its effect on rCBF assessment. Nucl Med Commun. 2011; 32(1):
63-70.
Morimoto Y, Ueno Y, Takeuchi W, Kojima S, Matsuzaki K, Ishitsu T, Umegaki
K, Kiyanagi Y, Kubo N, Katoh C, Shiga T, Shirato H, Tamaki N. Development
of a 3D brain PET scanner using CdTe semiconductor detectors and its first
clinical application. IEEE Trans Nucl Sci. 58(5):2181-2189, 2011
【 Review Articles, etc. 】
Kuge Y, Takei T, Zhao S: Feature 1 Next-Generation Molecular Imaging of
Tumors, 4. Apoptosis Imaging Probe. PET Journal. 13(Spring): 23-25, 2011
(in Japanese).
Kuge Y, Nishijima K, Zhao S: Feature 1 New Progress of Nuclear Medicine
Examination - Application to Treatment Strategy -, Development of Imaging
Agent Useful for Treatment Strategy, Medical Image Information. 43(11):
842-829, 2011 (in Japanese).
Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K,
Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine
phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme
imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3
Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection of membrane
type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting
method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9
Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H,
Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral
thalamic nucleus play an important role in anti-allodynic effects. Br J
Pharmacol. 2010; 159: 1201-1210.
Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation
and identification of new vasodilative substances in diesel exhaust particles.
Environ Sci Pollut Res Int. 2010;17(3):717-23.
Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New
NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.
Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound
for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono
M, Saji H: Tissue factor detection for selectively discriminating unstable
plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.
Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi
J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane
type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing
atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.
Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M,
Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible
factor-1-active tumours: pretargeted imaging with a protein degrading in
a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med
Mol Imaging. 2010;37(8):1566-1574.
【 Review Articles, etc. 】
Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.
Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment
of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.
Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki
N: Initial Performance Measurement of an Integrated PET/SPECT/CT System
for Small Animal Imaging. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.60-68.
Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular
Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG
and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy
and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business
Media), Heidelberger, 2010, pp.69-77.
Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation
for Central Nervous System Disorders Perspective for Translational Research
and Clinical Application. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.126-138.
Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge
Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal
Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.
Kuge Y, Nishijima K, Tamaki N: Chap. 18 Molecular Imaging of Nuclear Cardiology,
1. Imaging of Myocardial Sympathetic Nerve/Receptors (Yonekura Y, chief
editor; Ito M, Kubota K, Saji H, Tamaki N, Nakagawa K, Hatazawa J, Magata
Y, Watanabe Y, Terada H, eds.), Latest Clinical PET for Clinicians and
Healthcare Professionals Advanced Medical Technology Laboratory, Tokyo,
2010 (in Japanese).
Tamaki N, Yoshinaga K, Kuge Y: Chap. 1 History and Current Status of Molecular
Imaging of Cardiovascular Diseases (Imaizumi T, Narula J, supervisors;
Tahara N, ed.), Molecular Imaging of Cardiovascular Diseases, Nagai Shoten
Co., Ltd., Osaka, 2010 (in Japanese).
Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy
and Drug Development. Springer (Springer Science+Business Media), Heidelberger,
2010.