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Research Achievements of CIS


 2016

 2015

 2014

 2013

 2012

 2011

 2010


2016

【 Books 】

  1. Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N: Semiconductor Detector-Based Scanners for Nuclear Medicine. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;51-65.

  2. Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y: Development of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography Probe. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;113-124.

  3. Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y: Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 125-130.

  4. Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki N, Kuge Y: Discovery and Evaluation of Biomarkers for Atherosclerosis. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 131-139.

  5. Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y: Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 141-150.


【 Papers 】

  1. Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki N, Higashikawa K, Yasui H, Kuge Y: Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft. EJNMMI Res. 2016; 6(1): 90.

  2. Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima K, Magota K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy. Eur J Nucl Med Mol Imaging. 2016; 43(12): 2147-2154.

  3. Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y: Optimization of helical acquisition parameters to preserve uniformity of mouse whole body using multipinhole collimator in single-photon emission computed tomography. Results in Physics. 2016; 6: 659-663.

  4. Masaki Y, Shimizu Y, Yoshioka T, Feng F, Zhao S, Higashino K, Numata Y, Kuge Y: Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016; 11(8): e0161639.

  5. Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Ken-Ichi N, Tamaki N, Kuge Y: The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine. J Nucl Med. 2016; 57(8): 1276-81.

  6. Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R, Nakanishi H, Ozeki E, Kuge Y, Saji H. Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. PLoS One. 2016; 11(7) :e0159303.

  7. Toyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N: 18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumors. Eur J Nucl Med Mol Imaging. 2016 Jul;43(8):1469-76.

  8. Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y: Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochim Biophys Acta. 2016; 1861(8 Pt A): 688-702.

  9. Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y: Imaging mass spectrometry reveals acyl-chain- and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice. PLoS One. 2016; 11(3): e0152191.




2015

【 Papers 】

  1. Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M: Regulatory effect of interleukin-4 in the innate inflammatory response to Rhodococcus aurantiacus infection in mice. J Interferon Cytokine Res. 35(3): 222-231, 2015.

  2. Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki N: Oli-godendroglial component complicates the prediction of tumour grading with metabolic imaging. Eur J Nucl Med Mol Imaging. 42(6): 896-904, 2015

  3. Kobayashi K, Hirata K, Yamaguchi S, Manabe O, Terasaka S, Kobayashi H, Shiga T, Hattori N, Tanaka S, Kuge Y, Tamaki N: Prognostic value of volume-based measurements on (11)C-methionine PET in glioma patients. Eur J Nucl Med Mol Imaging. 42(7): 1071-1080, 2015

  4. Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y: Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med. 29(7): 582-587, 2015

  5. Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y: Combined plasma and tissue proteomic study of atherogenic model mouse: approach to eucidate mlecular dterminants in aherosclerosis dvelopment. J Proteome Res. 14(10): 4257-4269, 2015

  6. Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y: The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites. Sci Rep. 2015; 5:16802

  7. Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino H, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y: Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. Biochim Biophys Acta. 2015; 1851(12): 1554-65.

  8. Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H: Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[(11)C]Methylation with [(11)C]CH3I: Rapid Synthesis of [(11)C]Raclopride. Chem Pharm Bull (Tokyo). 2015; 63(9): 737-40.

  9. Yamaguchi A, Hanaoka H, Fujisawa Y, Zhao S, Suzue K, Morita A, Tominaga H, Higuchi T, Hisaeda H, Tsushima Y, Kuge Y, Iida Y: Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography. EJNMMI Res. 2015; 5: 29

  10. Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y: Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: Evaluation of hepatic distribution and metabolism in mice at various metabolic status induced by fasting in comparison with palmitic acid. Mol Imaging. 2015; 14(0): 1-11.

  11. Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y: Irbesartan attenuates atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits: Noninvasive imaging of inflammation by 18F-FDG PET. Mol Imaging. 2015; 14(0): 1-8




2014

【 Papers 】

  1. Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y: Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLOS One. 2014; 9(1): e86426.

  2. Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida T, Takemoto H, Tamaki N, Kuge Y: Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging with 14C-FDG and 99mTc-annexin A5. PLOS One. 2014; 9(2): e89338.

  3. Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada T, Horiguchi M, Hatate C, Kuge Y, Miwa S: A simple and rapid method for standard preparation of gas phase extract of cigarette smoke. PLOS ONE. 2014; 9(9): e107856.

  4. Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga T, Kuge Y, Tamaki N:Evaluation of delineation of image details in semiconductor PET utilizing the normalized mutual information technique;Nuclear Medicine Communications . 2014; 35(6): 677-682.

  5. Fatema CN, Zhao S, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y: Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer zerografts using radiolabaled FMISO and FLT. BMC Cancer. 2014; 14(1): 692.

  6. Oshima N, Akizawa H, Zhao S, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K: Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives. Bioorgan Med Chem. 2014; 22(4): 1377-1382.

  7. Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki N: Collimator for variable sensitivity and spatial resolution without the need for exchange. IEEE Trans Nucl Sci. 2014; 61(5): 2489-2493.

  8. Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H: In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel Activatable Near-Infrared Fluorescence Probe. Cancer Science. 2014; 105: 1056-62.

  9. Onoe S, Temma T, Shimizu Y, Ono M, Saji H: Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors. Cancer Medicine. 2014; 3: 775-86.

  10. Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji H: Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging of Cancer Biomolecules. Nanomedicine: Nanotechnology, Biology and Medicine. 2014; 10: 187-95.



2013

【 Papers 】

  1. Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S: 123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain. Stroke. 2013; 44(10): 2869-74.

  2. Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita H, Iwakiri T, Koshimoto C, Kawai K, Tamaki N, Kuge Y, Asada Y. 18F-FDG uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions. Circ J. 2013; 77(10): 2626-35.

  3. Zhao Y, Zhao S, Kuge Y, Tamaki N: Elevated 18F-FDG levels in blood and organs following angiotensin II receptor blocker administration: Experiment in mice administered telmisartan. J Nucl Med. 2013; 54(8): 1384-8.

  4. Murakami M, Zhao S, Zhao Y, Fatema CN, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y: Increased intratumoral fluorothymidine (FLT) uptake level after multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft. Oncol Lett. 2013; 6(3): 667-672.

  5. Noya Y, Seki KI, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S: Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity. Toxicology. 2013; 314(1): 1-10.

  6. Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Akita H, Tamaki N: Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression. BMC Cancer 2013; 13(1): 525.

  7. Yi M, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N: Contribution of Toll-Like Receptor 2 to the Response against Staphylococcus aureus Infection in Mice. PloS One. 2013; 8 (9): e74287.

  8. Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Inanami O. Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model. Biochem Biophys Res Commun. 2013; 437(3): 420-425.

  9. Sato J, Kitagawa Y, Yamazaki Y, Hata H, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N: 18F-Fluoromisonidazole PET Uptake Is Correlated with Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma. J Nucl Med. 2013; 54(7): 1060-5.

  10. Kawai T, Kawashima H, Kuge Y, Saji H: Synthesis and evaluation of 11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer's disease brain. Nucl Med Biol. 2013; 40(5): 705-9.

  11. Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Attenuation of apotosis by telmisartan in atherosclerotic plaques of apoE-/- mice: evaluation using 99mTc-annexin A5. Mol Imaging. 2013; 12(5): 300-9.

  12. Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa Y, Kuge Y: Monitoring tumor proliferative response to radiotherapy using 18F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67. Ann Nucl Med. 2013; 27(4): 355-62.

  13. Oashi K, Furukawa H, Nishihara H, Ozaki M, Oyama A, Funayama E, Hayashi T, Kuge Y, Yamamoto Y: Pathophysiological Characteristics of Melanoma In-Transit Metastasis in a Lymphedema Mouse Model. J Invest Dermatol. 2013; 133(2): 537-44

  14. Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N: High Reproducibility of Tumor Hypoxia Evaluated by 18F-Fluoromisonidazole PET for Head and Neck Cancer. J Nucl Med. 2013; 54(2): 201-7.

  15. Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N Kuge Y: Biological characteristics of intratumoral [F-18]fluoromisonidazole distribution in a rodent model of glioma. Int J Oncol. 2013; 42(3): 823-30.

  16. Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N: Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct. Neuropathology. 2013; 33(2): 140-8.

  17. Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R, Takeuchi W, Kuge Y, Tamaki N, Shirato H: [(18)F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer. Int J Radiat Oncol Biol Phys. 2013; 85(1): 142-7

  18. Miyamoto M, Kuroda S, Zhao S, Magota K, Maruichi K, Ito M, Kawabori M, Shichinohe H, Houkin K, Kuge Y, Tamaki N. Bone Marrow Stromal Cells Transplantation Enhances Recovery of Local Glucose Metabolism after Cerebral Infarct in Rats: A Serial 18F-FDG PET Study. J Nucl Med. 2013; 54(1): 145-50.

  19. Suzuki A, Takeuchi W, Ishitsu T, Tsuchiya K, Morimoto Y, Ueno Y, Kobashi K, Kubo N, Shiga T, Tamaki N: High-sensitivity brain SPECT system using cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator. Phys Med Biol. 2013;58(21):7715-31.

  20. Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, Ono M, Saji H.Miniaturized Antibodies for Imaging Membrane Type-1 Matrix Metalloproteinase in CancersCancer Sci. 104(4):495-501 (2013).




2012

【 Books 】

  1. Kuge Y, Tamaki N: E Prospect of Nuclear Cardiology, @ Molecular Imaging of Cardiovascular Diseases and Atherosclerosis (Nishimura T, ed.), BRAND NEW Nuclear Cardiology, Kanehara & Co., Ltd., Tokyo, 2012, pp. 248-254 (in Japanese).

  2. Yamauchi H, Kubo N, Tsuda K, Otani H, Kato S: Intensive Training of Important Problems in Type-I Radiation Protection Supervisor’s Examination (Fukushi M, ed.), Medical View Co., Ltd., Tokyo, 2012, pp. 90-152 (in Japanese).

  3. Kubo N: Chap. 4 Nuclear Medicine Examination Techniques, My Text to Pass National Examination of Radiological Technologists, 2013 (Ohmsha, Ltd., ed.), Ohmsha, Ltd., 2012, pp. 141-189 (in Japanese).

  4. Kubo N: Chap. 4 Radiochemistry, (Fukushi M, ed.), Pocket Review for Radiological Technologists, 2nd edition, Medical View Co., Ltd., Tokyo, 2012, pp. 121-146 (in Japanese).


【 Papers 】

  1. Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N: Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice. Biol Pharm Bull. 2012; 34 (12): 2214-2223.

  2. Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y: Quantitative Determination of Apoptosis of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus. J Nucl Med. 2012; 53(10):1585-91.

  3. Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y: Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma. Int J Oncol. 2012; 41(5): 1593-600.

  4. Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H: Norepinephrine Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated (2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine. Mol Imaging. 2012; 11(4): 280-5.

  5. Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G: Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012; 39: 1246-1253.

  6. Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, YamaguchiS, Houkin K, Tanaka S, Kuge Y, Tamaki N. 18F-Fluoromisonidazole positronemission tomography may differentiate glioblastoma multiforme from lessmalignant gliomas. Eur J Nucl Med Mol Imaging. 2012; 39(5): 760-70.

  7. Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N: Intracerebral, but not intravenous, transplantation of bone marrow stromal cells enhances functional recovery in rat cerebral infarct: An optical imaging study. Neuropathology. 2012; 32(3): 217-26.

  8. Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y, Tamaki N, Sasaki H: Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus. J Neurol Sci. 2012; 315(1-2): 55-9.

  9. Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y, Houkin K, Tamaki N, Iwasaki Y: Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats - In vivo cell tracking study by near infrared fluorescence imaging. Neurosurgery. 2012; 70(2): 435-44; discussion 444.

  10. Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H: A novel murine model for non-alcoholic steatohepatitis developedby combination of a high-fat diet and oxidized low-density lipoprotein.Lab Invest. 2012; 92(2): 265-81.

  11. Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N, Kuge Y: Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like Peptide 1. Ann Nucl Med. 2012; 26(2): 184-91.


【 Review Articles, etc. 】

  1. Kuge Y, Zhao Y, Zhao S, Tamaki N: Feature 1 Latest Nuclear Cardiology, 1. Imaging of Atherosclerosis - Experimental Examination -. PET Journal. 18(Summer): 14-16, 2012 (in Japanese).

  2. Kuge Y, Nishijima K, Magota K, Zhao S, Tamaki N: Current Status and Progress of Molecular Imaging in Drug Development. Pharmaceutical and Medical Device Regulatory Science Society of Japan. 43(4): 308-313, 2012 (in Japanese).

  3. Tamaki N, Yoshinaga K, Kuge Y: Sympathetic Nerve and Cardiovascular Diseases, Imaging of Sympathetic Nerve. Cardiac Practice. 23(2): 143-147, 2012 (in Japanese).

  4. Tamaki N, Yoshinaga K, Kuge Y: Advances in Diagnostic Imaging for Diagnosis and Treatment of Coronary Arterial Diseases, Evaluation of Coronary Lesions by Molecular Imaging. Cardiac Practice. 23(1): 23-27, 2012 (in Japanese).

  5. Fujishita T, Koura S, Kodama R, Ideguchi T, Kubo N, Ochi M: Misregistration of CT Attenuation-Corrected Cerebral Blood Flow SPECT Images: Impact on SPECT Counts. Japanese Journal of The Japan Association of Radiological Technologists. 59(5): 527-531, 2012 (in Japanese).

  6. Kubo N: Filter Back Projection and Successive Approximation. START. 48: 13-15, 2012 (in Japanese).

  7. Kubo N: To Improve the Molecular Imaging Techniques - Establishment and Practice of Educational Programs -. Collection of Abstracts of 2012 Annual Meeting on Safe Handling of Radiation by the Japan Radioisotope Association. 77-78, 2012 (in Japanese).

  8. Kubo N: Responsibility of Nuclear Medicine Specialist. Japanese Journal of Hokkaido Association of Radiological Technologists. 73: 39-41, 2012 (in Japanese).



2011

【 Books 】

  1. Kuge Y, Seki K: Chap. 9 Radiation and Living Organisms, 9.1 Effect of Ambient Radiation on Living Organisms, (Saji H, ed.), NEW Radiochemistry/Radiopharmaceutics, Hirokawa Shoten Co., Tokyo, 2011 (in Japanese).

  2. Tamaki N, Kuge Y: Nuclear Medicine Examination, Internal Therapy for Atherosclerosis, New Diagnostic Practice for Heart Disease 16 (Yoshikawa J, Kasanuki H, Haji K, Beppu S, Matsuzaki M, eds.), Bunkodo Co., Ltd., 2011, pp. 133-138 (in Japanese).

  3. Kubo N: Chap. 4 Nuclear Medicine Examination Techniques, My Text to Pass National Examination of Radiological Technologists (Ohmsha, Ltd., ed.), Ohmsha, Ltd., 2011, pp. 133-175 (in Japanese).


【 Papers 】

  1. Hua Li, Songji Zhao, Yongnan Jin, Ken-ichi Nishijima, Hiromichi Akizawa, Kazue Ohkura, Nagara Tamaki, Yuji Kuge: A radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown. Nucl Med Comn. 2011; 32 (12): 1211-5.

  2. Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H: A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents. Mol Imaging Biol. 2011; 13 (6): 1196-1203

  3. Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H: PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol Imaging Biol. 2011; 13 (5): 1003-10.

  4. Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N: Dynamic (11)C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET. Eur J Nucl Med Mol Imaging. 2011; 38(10): 1876-86.

  5. Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Localization of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with Macrophage Infiltration but not Lipid Deposition in the Lesion. Mol Imaging Biol. 2011; 13(4): 712-20.

  6. Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y: Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain. Neurosurgery. 2011; 68(4): 1036-47; discussion 1047.

  7. Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H: 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncol Rep. 2011; 26: 725-730.

  8. Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa H, Shono Y, Saji H, Minematsu K, Tamaki N. Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model. Neurosci Lett. 2011; 495(3): 210-215.

  9. Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima K, Kuge Y, Tamaki N: Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions. Ann Nucl Med. 2011; 25(3): 213-20.

  10. Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N: Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging. Eur J Nucl Med Mol Imaging. 2011; 38(4): 742-52.

  11. Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M, Hirata K, Saji H, Tamaki N, Minematsu K: Gene expression associated with an enriched environment after transient focal ischemia. Brain Res. 2011; 1376: 60-65

  12. Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y, Tamaki N: Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment. Nucl Med Commun. 2011; 32(1): 63-70.

  13. Morimoto Y, Ueno Y, Takeuchi W, Kojima S, Matsuzaki K, Ishitsu T, Umegaki K, Kiyanagi Y, Kubo N, Katoh C, Shiga T, Shirato H, Tamaki N. Development of a 3D brain PET scanner using CdTe semiconductor detectors and its first clinical application. IEEE Trans Nucl Sci. 58(5):2181-2189, 2011



【 Review Articles, etc. 】

  1. Kuge Y, Takei T, Zhao S: Feature 1 Next-Generation Molecular Imaging of Tumors, 4. Apoptosis Imaging Probe. PET Journal. 13(Spring): 23-25, 2011 (in Japanese).

  2. Kuge Y, Nishijima K, Zhao S: Feature 1 New Progress of Nuclear Medicine Examination - Application to Treatment Strategy -, Development of Imaging Agent Useful for Treatment Strategy, Medical Image Information. 43(11): 842-829, 2011 (in Japanese).




2010

【 Papers 】

  1. Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3

  2. Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9

  3. Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H, Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. Br J Pharmacol. 2010; 159: 1201-1210.

  4. Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation and identification of new vasodilative substances in diesel exhaust particles. Environ Sci Pollut Res Int. 2010;17(3):717-23.

  5. Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.

  6. Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.

  7. Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono M, Saji H: Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.

  8. Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.

  9. Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med Mol Imaging. 2010;37(8):1566-1574.


【 Review Articles, etc. 】

  1. Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.

  2. Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.

  3. Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki N: Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.60-68.

  4. Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.69-77.

  5. Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders Perspective for Translational Research and Clinical Application. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.126-138.

  6. Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.

  7. Kuge Y, Nishijima K, Tamaki N: Chap. 18 Molecular Imaging of Nuclear Cardiology, 1. Imaging of Myocardial Sympathetic Nerve/Receptors (Yonekura Y, chief editor; Ito M, Kubota K, Saji H, Tamaki N, Nakagawa K, Hatazawa J, Magata Y, Watanabe Y, Terada H, eds.), Latest Clinical PET for Clinicians and Healthcare Professionals Advanced Medical Technology Laboratory, Tokyo, 2010 (in Japanese).

  8. Tamaki N, Yoshinaga K, Kuge Y: Chap. 1 History and Current Status of Molecular Imaging of Cardiovascular Diseases (Imaizumi T, Narula J, supervisors; Tahara N, ed.), Molecular Imaging of Cardiovascular Diseases, Nagai Shoten Co., Ltd., Osaka, 2010 (in Japanese).

  9. Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy and Drug Development. Springer (Springer Science+Business Media), Heidelberger, 2010.




Central Institute of Isotope Science
Hokkaido University

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