Suzuki M, Matsuda T, Nakajima K, Yokouchi Y, Kuge Y, Ogawa M: PD1 blockade alters cell-cycle distribution and affects 3’-deoxy-3’-[18F]fluorothymidine uptake in a mouse CT26 tumor model. Ann Nucl Med. 2022; 36(11) :931-940.
Takamiya S, Kawabori M, Kitahashi T, Nakamura K, Mizuno Y, Yasui H, Kuge Y, Tanimori A, Takamatsu Y, Yuyama K, Shichinohe H, Fujimura M: Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model. Stem Cells Int. 2022: 8521922.
Nakajima K, Homma M, Suzuki M, Yokouchi Y, Matsuda T, Takakura H, Kuge Y, Ogawa M: Reduction of tumor hypoxia by anti-PD-1 therapy assessed using pimonidazole and [18F] FMISO. Nucl Med Biol. 2022; 108-109: 85-92.
Bo T, Yasui H, Shiga T, Shibata Y, Fujimoto M, Suzuki M, Higashikawa K, Miyamoto N, Inanami O, Kuge Y: Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human xenograft models. Eur J Nucl Med Mol Imaging. 2022; 49(3): 821-833.
Matsuya Y, Kai T, Parisi A, Yoshii Y, Sato, T: Application of a simple DNA damage model developed for electrons to proton irradiation. Phys Med Biol. 2022; 67(21).
Yachi Y, Kai T, Matsuya Y, Hirata Y, Yoshii Y, Date H: Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy. Sci Rep. 2022; 12(1).
Nakajima K, Homma M Suzuki M, Yokouchi Y, Matsuda T, Takakura H, Hirata K, Kuge Y, Ogawa M: Anti-PD-1 therapy reduces tumor hypoxia: evaluation with pimonidazole and [18F] fluoromisonidazole as hypoxia probes. AACR ANNUAL MEETING 2022, Ernest N. Morial Convention Center, New Orleans, LA. 2022. 04.08 – 13.
Ueno S, Some K, Oda T, Guerra F, Takahashi K, Nishijima K, Higuchi H, Shiga T, Kuge Y: Development of a high-yield and clinical grade cyclotron based 68Ga-PSMA-11 production system. The 13th Congress of the World Federation of Nuclear Medicine and Biology (WFNMB2022), Kyoto International Conference Center, Kyoto, Japan. 2022.09.07-11.
Mizuno Y, Kimura K, Onoe S, Shukuri M, Kuge Y, Akizawa H: Development of 99mTc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin αv β3. The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, Italy. 2022.09.14-17.
Mizuno Y, Kimura K, Onoe S, Shukuri M, Kuge Y, Akizawa H: Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ3. J Med Chem. 2021; 64(21): 16008-16019.
Yamaguchi S, Hirata K, Okamoto M, Shimosegawa E, Hatazawa J, Hirayama R, Kagawa N, Kishima H, Oriuchi N, Fujii M, Kobayashi K, Kobayashi H, Terasaka S, Nishijima KI, Kuge Y, Ito YM, Nishihara H, Tamaki N, Shiga T: Determination of Brain Tumor Recurrence using 11C-methionine Positron Emission Tomography after Radiotherapy. Cancer Sci. 2021; 112(10): 4246-4256.
Shibata Y, Yasui H, Higashikawa K, Kuge Y: Transferrin-based radiolabeled probe predicts the sensitivity of human renal cancer cell lines to ferroptosis inducer erastin. Biochem Biophys Rep. 2021; 26: 100957.
Manabe O, Yamaguchi S, Hirata K, Kobayashi K, Kobayashi H, Terasaka S, Toyonaga T, Magota K, Kuge Y, Tamaki N, Shiga T, Kudo K: Preoperative Texture Analysis Using 11C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma. Diagnostics (Basel). 2021; 11(2): 189.
Shimizu Y, Nakai Y, Watanabe H, Iikuni S, Ono M, Saji H, Kuge Y, Saga T, Nakamoto Y: Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors. EJNMMI Res. 2021; 11(1): 9.
Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M: Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment. Am J Pathol. 2021; 191(1): 144-156.
Yamasaki K, Zhao S, Nishimura M, Shimizu Y, Tamaki N, Takeda H, Kuge Y: Effects of feeding condition on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice Annals of Nuclear Medicine. Ann Nucl Med. 2021: 35(1): 59-64.
Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S: Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res. 2021; 117(3): 805-819.
【 総 説 な ど （英文）】
Satoh Y, Kawamoto M, Kubota K, Murakami K, Hosono M, Senda M, Sasaki M, Momose T, Ito K, Okamura T, Oda K, Kuge Y, Sakurai M, Tateishi U, Fujibayashi Y, Magata Y, Yoshida T, Waki A, Kato K, Hashimoto T, Uchiyama M, Kinuya S, Higashi T, Magata Y, Machitori A, Maruno H, Minamimoto R, Yoshinaga K: Clinical practice guidelines for high-resolution breast PET, 2019 edition. Ann Nucl Med. 2021; 35(3): 406-414.
Matsuya Y, Kai T, Sato T, Ogawa T, Hirata Y, Yoshii Y, Parisi A, Liamsuwan T: Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research. Int. J. Radiat. Oncol. Biol. Phys. 2021: 98(2): 148–157.
Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S: Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res. 2020: cvaa127.
Oiwa Y, Oka K, Yasui H, Higashikawa K, Bono H, Kawamura Y, Miyawaki S, Watarai A, Kikusui T, Shimizu A, Okano H, Kuge Y, Kimura K, Okamatsu-Ogura Y, Miura K: Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal. Sci Rep. 2020; 10(1): 19488.
Nishimoto Y, Nishio M, Nagashima S, Nakajima K, Ohira T, Nakai S, Nakase I, Higashikawa K, Kuge Y, Matsumoto A, Ogawa M, Kojima C: Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes. Polymers (Basel). 2020; 12(7): 1474.
Watanabe S, Nishijima KI, Okamoto S, Magota K, Hirata K, Toyonaga T, Shiga T, Kuge Y, Tamaki N: Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers. Ann Nucl Med. 2020; 34(8): 595-599.
Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Midori YA, Houkin K, Kawabori M: FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model. Transl Stroke Res. 2020; 11(5): 1103-1116.
Tomita M, Suzuki M, Kono Y, Nakajima K, Matsuda T, Kuge Y, Ogawa M: Influence on [18F]FDG uptake by cancer cells after anti PD-1 therapy in an enforced-immune activated mouse tumor. EJNMMI Res. 2020; 10(1): 24.
Kobayashi K, Manabe O, Hirata K, Yamaguchi S, Kobayashi H, Terasaka S, Toyonaga T, Furuya S, Magota K, Kuge Y, Kudo K, Shiga T, Tamaki N: Influence of the scan timepoint when assessing hypoxia in 18F-fluoromisonidazole PET: Two versus four hours. Eur J Nucl Med Mol Imaging 2020; 47(8):1833-1842.
Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C: Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting. Int J Pharm. 2020; 576: 119021.
Higashikawa K, Horiguchi S, Tarisawa M, Shibata Y, Ohkura K, Yasui H, Takeda H, Kuge Y: Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis. Nucl Med Biol. 2020; 82-83: 25-32.
Ohnishi A, Ishizuka C, Tsubakihara K, Hirata Y: Statistical double Λ hypernuclear formation from Ξ- absorption at rest in light nuclei. PTEP. 2020(6):063D01
Matsuya Y, Nakano T, Kai T, Shikazono N, Akamatsu K, Yoshii Y, Sato T: A simplified cluster analysis of electron track structure for estimating complex DNA damage yields. Int. J. Mol. Sci. 2020; 21(5), 1701.
【 総 説 な ど （英文）】
Gee AD, Andersson J, Bhalla R, Choe YS, Dick DW, Herth MM, Hostetler ED,
Jáuregui-Haza UJ, Huang YY, James ML, Jeong JM, Korde A, Kuge Y, Kung HF,
Lapi SE, Osso JA Jr, Parent E, Patt M, Pricile EF, Riss PJ, Santos-Oliveira
R, Taylor S, Vasdev N, Vercouillie J, Wadsak W, Yang Z, Zhu H, Scott PJH:
Training the next generation of radiopharmaceutical scientists. Nucl Med
Biol. 2020; 88-89: 10-13.
Hirata Y，Hirata K，Nasuhara Y，Shirato H：A study of new ethical risk management
method of medical Artificial Intelligence for radiotherapy，日本放射線腫瘍学会第３３回学術大会、オンライン開催、2020年10月1～3日
Shibata Y, Yasui H, Higashikawa K, Miyamoto N, Kuge Y: Erastin, a ferroptosis-inducing
agent, sensitized cancer cells to X-ray irradiation via glutathione starvation
in vitro and in vivo. PloS One 2019; 14(12): e0225931.
Higashikawa K, Horiguchi S, Tarisawa M, Shibata Y, Ohkura K, Yasui H, Takeda
H, Kuge Y: Preclinical investigation of potential use of thymidine phosphorylase-targeting
tracer for diagnosis of nonalcoholic steatohepatitis. Nucl Med Biol. 2019;
82-83: 25-32.
Watanabe S, Inoue T, Okamoto S, Magota K, Takayanagi A, Sakakibara-Konishi
J, Katoh N, Hirata K, Manabe O, Toyonaga T, Kuge Y, Shirato H, Tamaki N,
Shiga T: Combination of FDG-PET and FMISO-PET as a treatment strategy for
patients undergoing early-stage NSCLC stereotactic radiotherapy. EJNMMI
Res. 2019; 9(1): 104.
Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa
K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki
N: Biodistribution and radiation dosimetry of the novel hypoxia PET probe
[18F]DiFA and comparison with [18F]FMISO. EJNMMI Res. 2019; 9(1): 60.
Zhao S, Yu W, Ukon N, Tan C, Nishijima KI, Shimizu Y, Higashikawa K, Shiga
T, Yamashita H, Tamaki N, Kuge Y: Elimination of tumor hypoxia by eribulin
demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models.
EJNMMI Res. 2019 3; 9(1): 51.
Shimizu Y, Motomura A, Takakura H, Tamaki N, Kuge Y, Ogawa M: Accumulation
of hypoxia imaging probe "18F-FMISO" in macrophages depends on
macrophage polarization in addition to hypoxic state. Ann Nucl Med. 2019;
33(5): 362-367.
Kroenke M, Hirata K, Gafita A, Watanabe S, Okamoto S, Magota K, Shiga T,
Kuge Y, Tamaki N: Voxel based comparison and texture analysis of 18F-FDG
and 18F-FMISO PET of patients with head-and-neck cancer. PLoS One. 2019;
14(2): e0213111.
Nakata N, Kiriu M, Okumura Y, Zhao S, Nishijima KI, Shiga T, Tamaki N,
Kuge Y, Matsumoto H: Comparative evaluation of [18F]DiFA and its analogs
as novel hypoxia positron emission tomography and [18F]FMISO as the standard.
Nucl Med Biol. 2019; 70: 39-45.
Higashi T, Elmeligy E, Mai Y, Noya Y, Terada K, Mazaki Y, Kuge Y, Miwa
S: Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette
smoke by direct reacting with unsaturated carbonyl compounds in the gas
phase. BiochemBiophys Res Commun. 2019; 509(4): 988-993.
Shimizu Y, Zhao S, Yasui H, Nishijima K, Matsumoto H, Shiga T, Tamaki N,
Ogawa M, Kuge Y: A novel PET probe “[18F]DiFA” accumulates in hypoxic region
via glutathione conjugation following reductive metabolism. Mol Imaging
Biol. 2019; 21(1): 122-129.
Matsuya Y, Kai T, Yoshii Y, Yachi Y, Naijo S, Date H, & Sato T: Modeling
of yield estimation for DNA strand breaks based on Monte Carlo simulations
of electron track structure in liquid water. J Appl Phy. 2019; 126(12):
124701.
【 国 際 学 会 発 表 等 】
Shibata Y, Higashikawa K, Yasui H, kuge Y; A basic study on PET imaging
technique for predicting cancer sensitivity to ferroptosis-targeting cancer
therapy. The Society for Redox Biology and Medicine's 26th Annual Conference
(SfRBM 2019), Planet Hollywood Resort & Casino, Las Vegas, NV, 2019.
11.20-23.
Ogawa M. Tomita M., Yasui H., Higashikawa K., Nakajima K., Takakura H.,
Shiga T., Kuge Y. 32nd Annual EANM Congress, Centre de ConvencionsInternacional
de Barcelona, Barcelona, Spain, 2019.10.12-16
Sakata K, Asaka T, Ohga N, Sato J, Hirata K, Kuge Y, Shiga T, Kitagawa
Y: Role of 3-phase bone scintigraphy & FDG-PET to monitor hyperbaric
oxygen therapy for several types of refractory osteomyelitis. The 66th
annual meeting, Society of Nuclear Medicine and Molecular Imaging (SNMMI
2019), Anaheim Convention Center, Anaheim, CA, June 22 – June 25, 2019
(J Nucl Med 2019 60:1266).
Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge
Y, Ogawa M: Evaluation of [18F]FDG uptake after anti PD-1 therapy in mice.
The 66th annual meeting, Society of Nuclear Medicine and Molecular Imaging
(SNMMI 2019), Anaheim Convention Center, Anaheim, CA, June 22 – June 25,
2019 (J Nucl Med 2019 60:1403)
Kitagawa Y, Asaka T, Sakata K, Ohga N, Sato J, Hata H, Hirata K, Kuge Y,
Shiga T: Usefulness of FDG-PET combined with 3-phase bone scintigraphy
to evaluate the activity of refractory chronic osteomyelitis of the Jaw.
The 66th annual meeting, Society of Nuclear Medicine and Molecular Imaging
(SNMMI 2019), Anaheim Convention Center, Anaheim, CA, June 22 – June 25,
2019 (J Nucl Med 2019 60:1072)
Watanabe S, Takayanagi A, Hirata K, Inoue T, Okamoto S, Toyonaga T, Magota
K, Kuge Y, Shirato H, Tamaki N, Shiga T: Combination of FDG and FMISO may
predict accurate PFS in patients with early-stage NSCLC after stereotactic
radiotherapy. The 66th annual meeting, Society of Nuclear Medicine and
Molecular Imaging (SNMMI 2019), Anaheim Convention Center, Anaheim, CA,
June 22 – June 25, 2019 (J Nucl Med 2019 60:150)
Yasui H, Higashikawa K, Shibata Y, Matsumoto H, Shiga T, Tamaki N, Kuge
Y: Preclinical evaluation of [18F]DiFA, a novel hypoxia PET probe, in a
rat intracranial glioma model. The 23rd International Symposium on Radiopharmaceutical
Science (ISRS 2019), Beijing International Convention Center, Beijing,
China, 2019.05.26-31.
Higashikawa K, Uehara R, Horiguchi S, Shibata Y, Tarisawa M, Kitaura H,
Yasui H, Takeda H, Kuge Y: Investigation of the potentials of a thymidine
phosphorylase imaging probe for the differential diagnosis of nonalcoholic
steatohepatitis. The 23rd International Symposium on Radiopharmaceutical
Science (ISRS 2019), Beijing International Convention Center, Beijing,
China, 2019.05.26-31.
Yuji Kuge: Potential Use of Hypoxia and Thymidine Phosphorylase Imaging
Probes for Theranostics. Scientific Session 3-1 “Next Generation Theranostics
(from Chemists' Point of View) - Novel Targets and Probes”. 5th Theranostics
World Congress 2019, The ShillaJeju Hotel, Jeju, Korea. 2019.03.01-03.
Abiko K, Shiga T, Katoh C, Hirata K, Kuge Y, Kobayashi K, Ikeda S, Ikoma
K: Relationship between intelligence quotient (IQ) and cerebral metabolic
rate of oxygen in patients with neurobehavioural disability after traumatic
brain injury. Brain Inj. 2018; 32(11): 1367-1372.
Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge
Y, Ogawa M: Anti PD-1 treatment increases [18F]FDG uptake by cancer cells
in a mouse B16F10 melanoma model. EJNMMI Res. 2018; 8(1): 82.
Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N,
Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K:
[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration
of bone marrow stromal cells after transient focal ischemia. EJNMMI Res.
2018; 8(1) :35.
Komatsu Y, Nishijima K, Oomagari S, Kanai Y, Naka S, Higashikawa K, Ebita
Y, Shiga T, Hatazawa J, Tamaki N, Kuge Y: Measurement of Iodine-Derived
Contamination in L-[11C]Methionine Injection. RADIOISOTOPES, 2018; 67,
75–83.
Yamasaki K, Yamashita A, Zhao Y, Shimizu Y, Nishii R, Kawai K, Tamaki N,
Zhao S, Asada Y, Kuge Y: In Vitro Uptake and Metabolism of [14C]Acetate
in Rabbit Atherosclerotic Arteries: Biological Basis for Atherosclerosis
Imaging with [11C]Acetate. Nucl Med Biol. 2018; 56: 21-25.
【 国 際 学 会 発 表 等 】
Yasui H, Higashikawa K, Shimizu Y, Shibata Y, Zhao S, Matsumoto H, Shiga
T, Tamaki N, Kuge Y: Investigation of the influence of intratumoral glutathione
status on the distribution of a hypoxic probe [18F]FMISO. WFNMB 2018, Melbourne
Exhibition and Convention Centre, Melbourne, Australia 2018.4.20-24
Watanabe S, Shiga T, Magota K, Hirata K, Okamoto S, Toyonaga T, Higashikawa
K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki
N: [18F]DiFA, a new hypoxic imaging PET probe: A first human study in healthy
subjects. WFNMB 2018, Melbourne Exhibition and Convention Centre, Melbourne,
Australia 2018.4.20-24
Higashikawa K, Horiguchi S, Ebita Y, Tarisawa M, Komatsu Y, Ohkura K, Yasui
H, Takeda H, Kuge Y: Feasibility and potentials of thymidine phosphorylase
(TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis
of non-alcoholic steatohepatitis. The 65th annual meeting, Society of Nuclear
Medicine and Molecular Imaging (SNMMI 2018), Pennsylvania Convention Center,
Philadelphia, PA 2018.6.23-26 (J Nucl Med 2018 59:1084)
Shimizu Y, Nakai Y, Watanabe H, Ono M, Saji H, Kuge Y, Nakamoto Y, Saga
T, Togashi K: FMISO-PET imaging may be affected by inhibitors of multidrug-resistant
protein 1 independent of the hypoxic state. The 65th annual meeting, Society
of Nuclear Medicine and Molecular Imaging (SNMMI 2018), Pennsylvania Convention
Center, Philadelphia, PA 2018.6.23-26 (J Nucl Med 2018 59:1251).
Higashikawa K, Horiguchi S, Uehara R, Tarisawa M, Shibata Y, Kitaura H,
Yasui H, Takeda H, Kuge Y: Potentials of a thymidine phosphorylase imaging
agent in the diagnosis of nonalcoholic steatohepatitis. 10th China-Japan-Korea
Symposium on Radiopharmaceutical Sciences (CJKSRS2018), Xiamen University,
Xiamen, China 2018.11.2-4
Masaki Y, Shimizu Y, Yoshioka T, Nishijima K, Zhao S, Higashino K, Numata
Y, Tamaki N, Kuge Y: FMISO accumulation in tumor is dependent on glutathione
conjugation capacity in addition to hypoxic state. Ann Nucl Med. 2017;
31: 596–604
Nishikawa Y, Yasuda K, Okamoto S, Ito YM, Onimaru R, Shiga T, Tsuchiya
K, Watanabe S, Takeuchi W, Kuge Y, Peng H, Tamaki N, Shirato H: Local relapse
of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using
PET with semiconductor detectors. Radiation Oncology. 2017; 12: 148
Oshima N, Akizawa H, Kitaura H, Kawashima H, Zhao S, Zhao Y, Nishijima
KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K: 111In-DTPA-d-Phe-1-Asp0-d-Phe1-octreotide
exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-d-Phe1-octreotide.
Nucl Med Biol. 2017; 54: 18-26.
Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao
S, Tamaki N, Ogawa M, Kuge Y: Immunoglobulin G (IgG)-Based Imaging Probe
Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent
of IgG Target Molecule Expression. Mol Imaging Biol. 2017; 19(4): 531-539.
Sato J, Kitagawa Y, Watanabe S, Asaka T, Ohga N, Hirata K, Okamoto S, Shiga
T, Shindoh M, Kuge Y, Tamaki N: 18F-Fluoromisonidazole positron emission
tomography (FMISO-PET) may reflect hypoxia and cell proliferation activity
in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol.
2017; 124(3): 261-270.
Yu W, Zhao S, Zhao Y, Fatema CN, Murakami M, Nishijima KI, Kitagawa Y,
Tamaki N, Kuge Y: Changes in tumor oxygen state after sorafenib therapy
evaluated by 18F-fluoromisonidazole hypoxia imaging of renal cell carcinoma
xenograft. Oncology Lett 2017; 14: 2341-2346.
Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C, Koshimoto
C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y: Altered glucose
metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis
in rabbits. PLoS One. 2017; 12(4): e0175976.
Toyonaga T, Yamaguchi S, Hirata K, Kobayashi K, Manabe O, Watanabe S, Terasaka
S, Kobayashi H, Hattori N, Shiga T, Kuge Y, Tanaka S, Ito YM, Tamaki N:
Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor.
Eur J Nucl Med Mol Imaging. 2017; 44(4): 611-619.
Abiko K, Ikoma K, Shiga T, Katoh C, Hirata K, Kuge Y, Kobayashi K, Tamaki
N: I-123 iomazenil single photon emission computed tomography for detecting
loss of neuronal integrity in patients with traumatic brain injury. EJNMMI
Res. 2017; 7(1): 28
Oshima N, Akizawa H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura
Y, Arano Y, Kuge Y, Ohkura K: Redesign of negatively charged 111In-DTPA-octreotide
derivative to reduce renal radioactivity. Nucl Med Biol. 2017; 48: 16-25.
Yamamori T, Sasagawa T, Ichii O, Hiyoshi M, Bo T, Yasui H, Kon Y, Inanami
O: Analysis of the mechanism of radiation-induced upregulation of mitochondrial
abundance in mouse fibroblasts. J Radiat Res. 2017; 58(3): 292-301
Kubota H, Komarov DA, Yasui H, Matsumoto S, Inanami O, Kirilyuk IA, Khramtsov
VV, Hirata H: Feasibility of in vivo three-dimensional T2* mapping using
dicarboxy-PROXYL and CW-EPR-based single-point imaging. Magn Reson Mater
Phys Biol Med. 2017; 30(3): 291-298.
Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori
T, Yamasaki T, Yamada KI, Inanami O: Lipophilic triphenylphosphonium derivatives
enhance radiation-induced cell killing via inhibition of mitochondrial
energy metabolism in tumor cells. Cancer Lett. 2017; 390(1): 160-167.
Sun L, Moritake T, Ito K, Matsumoto Y, Yasui H, Nakagawa H, Hirayama A,
Inanami O, Tsuboi K: Metabolic analysis of radioresistant medulloblastoma
stem-like clones and potential therapeutic targets. PLoS One. 2017; 12(4):
e0176162.
Yasui H, Kawai T, Saito K, Matsumoto S, Devasahayam N, Mitchell JB, Camphausen
K, Inanami O, Krishna MC: Quantitative imaging of pO2 in orthotopic murine
gliomas: Hypoxia correlates with resistance to radiation. Free Radic Res.
2017; 51(9-10): 861-871.
Chowdhury Nusrat Fatema, Takeshi Kuroshima, Takuya Asaka, Takahiro Abe,
Jun Sato, Tohru Shiga, Yuji Kuge, Nagara Tamaki, and Yoshimasa Kitagawa:
Prognostic value of MET-PET in oral cancer. The 64th annual meeting, Society
of Nuclear Medicine and Molecular Imaging, Denver, CO, June 10 –14, 2017
(J Nucl Med 2017 58:285)
Shozo Okamoto, Tohru Shiga, Koichi Yasuda, Shiro Watanabe, Keiichi Magota,
Rikiya Onimaru, Kazuhiko Tsuchiya, Yuji Kuge, and Nagara Tamaki: FMISO-PET
during intensity-modulated radiotherapy can predict more accurately than
pre-therapeutic and post- therapeutic PET for head and neck cancer. The
64th annual meeting, Society of Nuclear Medicine and Molecular Imaging,
Denver, CO, June 10 –14, 2017 (J Nucl Med 2017 58:283)
Shiro Watanabe, Shozo Okamoto, Kenji Hirata, Tohru Shiga, Takuya Toyonaga,
Kentaro Kobayashi, Osamu Manabe, Yuko Uchiyama, Junya Katahata, Yamato
Munakata, Keiichi Magota, Ken-ichi Nishijima, Yuji Kuge, and Nagara Tamaki:
First-in-Human Study of [18F] DiFA, an improved PET probe for tumor hypoxia,
in Six Healthy Volunteers. The 64th annual meeting, Society of Nuclear
Medicine and Molecular Imaging, Denver, CO, June 10 –14, 2017. (J Nucl
Med 2017 58:839)
Yoichi Shimizu, Songji Zhao, Reimi Kishi, Hironobu Yasui, Ken-ichi Nishijima,
Hiroki Matsumoto, Nagara Tamaki, Mikako Ogawa, and Yuji Kuge: Accumulation
mechanism of novel PET imaging probe “[18F]DiFA” in hypoxic cells revealed
by imaging mass spectrometry. The 64th annual meeting, Society of Nuclear
Medicine and Molecular Imaging, Denver, CO, June 10 –14, 2017. (J Nucl
Med 2017 58:680)
Takuya Toyonaga, Tohru Shiga, Kenji Hirata, Shigeru Yamaguchi, Wataru Takeuchi,
Kohsuke Kudo, Keiichi Magota, Osamu Manabe, Kentaro Kobayashi, Shiro Watanabe,
Yuji Kuge, and Nagara Tamaki: Convolutional neural network (CNN) of MRI
and FDG-PET images may predict hypoxia in glioblastoma. The 64th annual
meeting, Society of Nuclear Medicine and Molecular Imaging, Denver, CO,
June 10 –14, 2017. (J Nucl Med 2017 58:699)
Jun Sato, Yoshimasa Kitagawa, Shiro Watanabe, SHOZO OKAMOTO, Noritaka Ohga,
Takuya Asaka, Masaaki Miyakoshi, Kenji Hirata, Tohru Shiga, Yuji Kuge,
Masanobu Shibndoh, and Nagara Tamaki: 18F-Fluoromisonidazole positron emission
tomography (FMISO-PET) may better reflect hypoxia and cell proliferation
activity in oral squamous cell carcinoma than 18F-fluoro-2-deoxyglucose
(FDG)-PET: the third study. The 64th annual meeting, Society of Nuclear
Medicine and Molecular Imaging, Denver, CO, June 10 –14, 2017. (J Nucl
Med 2017 58:284)
Hironobu Yasui, Songji Zhao, Kei Higashikawa, Naoyuki Ukon, Yoichi Shimizu,
Hiroki Matsumoto, Nagara Tamaki, and Yuji Kuge: Preclinical evaluation
of [18F]DiFA, a novel PET probe for tumor hypoxia, in comparison with [18F]MISO.
The 64th annual meeting, Society of Nuclear Medicine and Molecular Imaging,
Denver, CO, June 10 –14, 2017. (J Nucl Med 2017 58:1027)
Shiro Watanabe, Tohru Shiga, Kenji Hirata, Tetsuya Inoue, SHOZO OKAMOTO,
Takuya Toyonaga, Keiichi Magota, Ken-ichi Nishijima, Yuji Kuge, and Nagara
Tamaki: Predicting hypoxia using texture parameters on CT in patients with
non-small cell lung cancer. The 64th annual meeting, Society of Nuclear
Medicine and Molecular Imaging, Denver, CO, June 10 –14, 2017. (J Nucl
Med 2017 58:147)
Songji Zhao, Wenwen Yu, Naoyuki Ukon, Ken-ichi Nishijima, Yoichi Shimizu,
Kei Higashikawa, Hiroko Yamashita, Nagara Tamaki, and Yuji Kuge: Effect
of eribulin on remodeling of tumor vascular confirmed by FMISO PET imaging-The
small animal PET study in a human breast cancer cell xenograft. The 64th
annual meeting, Society of Nuclear Medicine and Molecular Imaging, Denver,
CO, June 10 –14, 2017. (J Nucl Med 2017 58:323)
Harue Kubota, Denis A. Komarov, Shingo Matsumoto, Kumiko Yamamoto, Hironobu
Yasui, Osamu Inanami, Igor A. Kirilyuk, Valery V. Khramtsov, and Hiroshi
Hirata: Three-dimensional oxygen mapping using a pair of isotopic nitroxyl
radicals and CW-EPR-based single-point imaging. International Conference
on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological
Systems (EPR-2017), Morgantown, WV, July 16-22, 2017
Hironobu Yasui: Application of electron spin resonance (ESR/EPR) pO2 and
redox imaging to improve cancer radiotherapy, 2017 KSMI-FASMI Joint Conference,
Seoul, Korea, August 25-26, 2017
Hironobu Yasui, Tatsuya Kawai, Shingo Matsumoto, Keita Saito, Nallathamby
Devasahayam, James B. Mitchell, Kevin Camphausen, Osamu Inanami, and Murali
C. Krishna: Quantitative pO2 mapping using electron paramagnetic resonance
imaging in orthotopic murine glioma, The 24th annual meeting, The Society
for Redox Biology and Medicine, Baltimore, MD, November 29- December 2,
2017.
Norihito Nakata, Masato Kiriu, Yuki Okumura, Yuji Kuge, Hiroki Matsumoto:
Evaluation of the Utility of [18F]DiFA as a Novel Renal Hypoxia Imaging
Tracer. Kidney Week 2017, American Society of Nephrology. New Orleans,
LA, Oct. 31- Nov. 5, 2017.
Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki
N, Higashikawa K, Yasui H, Kuge Y: Dynamic PET evaluation of elevated FLT
level after sorafenib treatment in mice bearing human renal cell carcinoma
xenograft. EJNMMI Res. 2016; 6(1): 90.
Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima K, Magota
K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: The reoxygenation
of hypoxia and the reduction of glucose metabolism in head and neck cancer
by fractionated radiotherapy with intensity-modulated radiation therapy.
Eur J Nucl Med Mol Imaging. 2016; 43(12): 2147-2154.
Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y: Optimization of helical
acquisition parameters to preserve uniformity of mouse whole body using
multipinhole collimator in single-photon emission computed tomography.
Results in Physics. 2016; 6: 659-663.
Masaki Y, Shimizu Y, Yoshioka T, Feng F, Zhao S, Higashino K, Numata Y,
Kuge Y: Imaging Mass Spectrometry Revealed the Accumulation Characteristics
of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia.
PLoS One. 2016; 11(8): e0161639.
Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura
K, Ken-Ichi N, Tamaki N, Kuge Y: The Thymidine Phosphorylase Imaging Agent
123I-IIMU Predicts the Efficacy of Capecitabine. J Nucl Med. 2016; 57(8):
1276-81.
Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R,
Nakanishi H, Ozeki E, Kuge Y, Saji H. Continuous-Flow Synthesis of N-Succinimidyl
4-[18F]fluorobenzoate Using a Single Microfluidic Chip. PLoS One. 2016;
11(7) :e0159303.
Toyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi
K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N: 18F-fluoromisonidazole
positron emission tomography can predict pathological necrosis of brain
tumors. Eur J Nucl Med Mol Imaging. 2016 Jul;43(8):1469-76.
Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka
T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge
Y: Characterization of the role of sphingomyelin synthase 2 in glucose
metabolism in whole-body and peripheral tissues in mice. Biochim Biophys
Acta. 2016; 1861(8 Pt A): 688-702.
Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y,
Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y: Imaging mass spectrometry
reveals acyl-chain- and region-specific sphingolipid metabolism in the
kidneys of sphingomyelin synthase 2-deficient mice. PLoS One. 2016; 11(3):
e0152191.
【 英 文 総 説 】
Shimizu Y, Kuge Y: Recent Advances in the Development of PET/SPECT Probes
for Atherosclerosis Imaging. Nuclear Medicine and Molecular Imaging. Nuclear
Medicine and Molecular Imaging, 2016; 50(4): 284-291.
【 英 文 編 書 】
Kuge Y, Shiga T, Tamaki N (eds.) “Molecular Imaging for Perspectives on
Nuclear Medicine for Molecular Diagnosis and Integrated Therapy”, Springer
(Springer Science+Business Media), Heidelberger, 2016.
【 英 文 著 書 】
Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge
Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N: Semiconductor
Detector-Based Scanners for Nuclear Medicine. In: Perspectives on Nuclear
Medicine for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016;51-65.
Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y: Development
of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography
Probe. In: Perspectives on Nuclear Medicine for Molecular Diagnosis and
Integrated Therapy. Springer Japan.2016;113-124.
Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N,
Kuge Y: Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe,
[123I]IIMU, for Translational Research. In: Perspectives on Nuclear Medicine
for Molecular Diagnosis and Integrated Therapy. Springer Japan.2016; 125-130.
Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S,
Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki
N, Kuge Y: Discovery and Evaluation of Biomarkers for Atherosclerosis.
In: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated
Therapy. Springer Japan.2016; 131-139.
Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S,
Tamaki N, Kuge Y: Radioimmunodetection of Atherosclerotic Lesions Focusing
on the Accumulation Mechanism of Immunoglobulin G. In: Perspectives on
Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Springer
Japan.2016; 141-150.
Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M: Regulatory
effect of interleukin-4 in the innate inflammatory response to Rhodococcus
aurantiacus infection in mice. J Interferon Cytokine Res. 35(3): 222-231,
2015.
Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi
H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki
N: Oli-godendroglial component complicates the prediction of tumour grading
with metabolic imaging. Eur J Nucl Med Mol Imaging. 42(6): 896-904, 2015
Kobayashi K, Hirata K, Yamaguchi S, Manabe O, Terasaka S, Kobayashi H,
Shiga T, Hattori N, Tanaka S, Kuge Y, Tamaki N: Prognostic value of volume-based
measurements on (11)C-methionine PET in glioma patients. Eur J Nucl Med
Mol Imaging. 42(7): 1071-1080, 2015
Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki
N, Kuge Y: Relationship between biodistribution of a novel thymidine phosphorylase
(TP) imaging probe and TP expression levels in normal mice. Ann Nucl Med.
29(7): 582-587, 2015
Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge
Y: Combined plasma and tissue proteomic study of atherogenic model mouse:
approach to eucidate mlecular dterminants in aherosclerosis dvelopment.
J Proteome Res. 14(10): 4257-4269, 2015
Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino
K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y: The accumulation
mechanism of the hypoxia imaging probe "FMISO" by imaging mass
spectrometry: possible involvement of low-molecular metabolites. Sci Rep.
2015; 5:16802
Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino H,
Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y: Histological analyses
by matrix-assisted laser desorption/ionization-imaging mass spectrometry
reveal differential localization of sphingomyelin molecular species regulated
by particular ceramide synthase in mouse brains. Biochim Biophys Acta.
2015; 1851(12): 1554-65.
Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki
E, Kuge Y, Saji H: Application of Microreactor to the Preparation of C-11-Labeled
Compounds via O-[(11)C]Methylation with [(11)C]CH3I: Rapid Synthesis of
[(11)C]Raclopride. Chem Pharm Bull (Tokyo). 2015; 63(9): 737-40.
Yamaguchi A, Hanaoka H, Fujisawa Y, Zhao S, Suzue K, Morita A, Tominaga
H, Higuchi T, Hisaeda H, Tsushima Y, Kuge Y, Iida Y: Differentiation of
malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine
positron emission tomography. EJNMMI Res. 2015; 5: 29
Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K,
Tamaki N, Takeda H, Kuge Y: Radiolabeled BMIPP for imaging hepatic fatty
acid metabolism: Evaluation of hepatic distribution and metabolism in mice
at various metabolic status induced by fasting in comparison with palmitic
acid. Mol Imaging. 2015; 14(0): 1-11.
Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo
N, Ukon N, Nakano T, Tamaki N, Kuge Y: Irbesartan attenuates atherosclerosis
in Watanabe Heritable Hyperlipidemic rabbits: Noninvasive imaging of inflammation
by 18F-FDG PET. Mol Imaging. 2015; 14(0): 1-8
Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C,
Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada
Y: Increased metabolite levels of glycolysis and pentose phosphate pathway
in rabbit atherosclerotic arteries and hypoxic macrophage. PLOS One. 2014;
9(1): e86426.
Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida
T, Takemoto H, Tamaki N, Kuge Y: Suppressive effects of irbesartan on inflammation
and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging
with 14C-FDG and 99mTc-annexin A5. PLOS One. 2014; 9(2): e89338.
Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada
T, Horiguchi M, Hatate C, Kuge Y, Miwa S: A simple and rapid method for
standard preparation of gas phase extract of cigarette smoke. PLOS ONE.
2014; 9(9): e107856.
Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga
T, Kuge Y, Tamaki N：Evaluation of delineation of image details in semiconductor
PET utilizing the normalized mutual information technique；Nuclear Medicine
Communications . 2014; 35(6): 677-682.
Fatema CN, Zhao S, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge
Y: Dual tracer evaluation of dynamic changes in intratumoral hypoxic and
proliferative states after radiotherapy of human head and neck cancer zerografts
using radiolabaled FMISO and FLT. BMC Cancer. 2014; 14(1): 692.
Oshima N, Akizawa H, Zhao S, Nishijima K, Kitamura Y, Arano Y, Kuge Y,
Ohkura K: Design, synthesis and biological evaluation of negatively charged
111In-DTPA-octreotide derivatives. Bioorgan Med Chem. 2014; 22(4): 1377-1382.
Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki
N: Collimator for variable sensitivity and spatial resolution without the
need for exchange. IEEE Trans Nucl Sci. 2014; 61(5): 2489-2493.
Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H:
In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel
Activatable Near-Infrared Fluorescence Probe. Cancer Science. 2014; 105:
1056-62.
Onoe S, Temma T, Shimizu Y, Ono M, Saji H: Investigation of cyanine dyes
for in vivo optical imaging of altered mitochondrial membrane potential
in tumors. Cancer Medicine. 2014; 3: 775-86.
Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji
H: Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging
of Cancer Biomolecules. Nanomedicine: Nanotechnology, Biology and Medicine.
2014; 10: 187-95.
Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki
N, Kuroda S: 123I-Iomazenil Single Photon Emission Computed Tomography
Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy
in Rat Infarct Brain. Stroke. 2013; 44(10): 2869-74.
Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita H, Iwakiri T, Koshimoto
C, Kawai K, Tamaki N, Kuge Y, Asada Y. 18F-FDG uptake reflects thrombus
formation and tissue factor expression via nuclear factor-κB in rabbit
atherosclerotic lesions. Circ J. 2013; 77(10): 2626-35.
Zhao Y, Zhao S, Kuge Y, Tamaki N: Elevated 18F-FDG levels in blood and
organs following angiotensin II receptor blocker administration: Experiment
in mice administered telmisartan. J Nucl Med. 2013; 54(8): 1384-8.
Murakami M, Zhao S, Zhao Y, Fatema CN, Yu W, Nishijima K, Takiguchi M,
Tamaki N, Kuge Y: Increased intratumoral fluorothymidine (FLT) uptake level
after multikinase inhibitor sorafenib treatment in a human renal cell carcinoma
xenograft. Oncol Lett. 2013; 6(3): 667-672.
Noya Y, Seki KI, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate
C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S: Identification of stable
cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological
characterization of their cytotoxicity. Toxicology. 2013; 314(1): 1-10.
Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Akita H,
Tamaki N: Assessment of early changes in 3H-fluorothymidine uptake after
treatment with gefitinib in human tumor xenograft in comparison with Ki-67
and phospho-EGFR expression. BMC Cancer 2013; 13(1): 525.
Yi M, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N: Contribution
of Toll-Like Receptor 2 to the Response against Staphylococcus aureus Infection
in Mice. PloS One. 2013; 8 (9): e74287.
Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura
H, Fujii H, Inanami O. Radiation-induced nitric oxide mitigates tumor hypoxia
and radioresistance in a murine SCCVII tumor model. Biochem Biophys Res
Commun. 2013; 437(3): 420-425.
Sato J, Kitagawa Y, Yamazaki Y, Hata H, Okamoto S, Shiga T, Shindoh M,
Kuge Y, Tamaki N: 18F-Fluoromisonidazole PET Uptake Is Correlated with
Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma.
J Nucl Med. 2013; 54(7): 1060-5.
Kawai T, Kawashima H, Kuge Y, Saji H: Synthesis and evaluation of 11C-labeled
naphthalene derivative as a novel non-peptidergic probe for the β-secretase
(BACE1) imaging in Alzheimer's disease brain. Nucl Med Biol. 2013; 40(5):
705-9.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Attenuation
of apotosis by telmisartan in atherosclerotic plaques of apoE-/- mice:
evaluation using 99mTc-annexin A5. Mol Imaging. 2013; 12(5): 300-9.
Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa
Y, Kuge Y: Monitoring tumor proliferative response to radiotherapy using
18F-fluorothymidine in human head and neck cancer xenograft in comparison
with Ki-67. Ann Nucl Med. 2013; 27(4): 355-62.
Oashi K, Furukawa H, Nishihara H, Ozaki M, Oyama A, Funayama E, Hayashi
T, Kuge Y, Yamamoto Y: Pathophysiological Characteristics of Melanoma In-Transit
Metastasis in a Lymphedema Mouse Model. J Invest Dermatol. 2013; 133(2):
537-44
Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato
H, Tamaki N: High Reproducibility of Tumor Hypoxia Evaluated by 18F-Fluoromisonidazole
PET for Head and Neck Cancer. J Nucl Med. 2013; 54(2): 201-7.
Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki
N Kuge Y: Biological characteristics of intratumoral [F-18]fluoromisonidazole
distribution in a rodent model of glioma. Int J Oncol. 2013; 42(3): 823-30.
Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N:
Timing and cell dose determine therapeutic effects of bone marrow stromal
cell transplantation in rat model of cerebral infarct. Neuropathology.
2013; 33(2): 140-8.
Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R,
Takeuchi W, Kuge Y, Tamaki N, Shirato H: [(18)F]fluoromisonidazole and
a New PET System With Semiconductor Detectors and a Depth of Interaction
System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer.
Int J Radiat Oncol Biol Phys. 2013; 85(1): 142-7
Miyamoto M, Kuroda S, Zhao S, Magota K, Maruichi K, Ito M, Kawabori M,
Shichinohe H, Houkin K, Kuge Y, Tamaki N. Bone Marrow Stromal Cells Transplantation
Enhances Recovery of Local Glucose Metabolism after Cerebral Infarct in
Rats: A Serial 18F-FDG PET Study. J Nucl Med. 2013; 54(1): 145-50.
Suzuki A, Takeuchi W, Ishitsu T, Tsuchiya K, Morimoto Y, Ueno Y, Kobashi
K, Kubo N, Shiga T, Tamaki N: High-sensitivity brain SPECT system using
cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator.
Phys Med Biol. 2013;58(21):7715-31.
Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, Ono M, Saji
H.Miniaturized Antibodies for Imaging Membrane Type-1 Matrix Metalloproteinase
in CancersCancer Sci. 104(4):495-501 (2013)．
Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N: Ferrous Ferric Chloride
Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection
in Mice. Biol Pharm Bull. 2012; 34 (12): 2214-2223.
Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss
HW, Blankenberg FG, Tamaki N, Kuge Y: Quantitative Determination of Apoptosis
of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus. J
Nucl Med. 2012; 53(10):1585-91.
Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi
M, Tamaki N, Kuge Y: Evaluation of changes in the tumor microenvironment
after sorafenib therapy by sequential histology and 18F-fluoromisonidazole
hypoxia imaging in renal cell carcinoma. Int J Oncol. 2012; 41(5): 1593-600.
Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H: Norepinephrine
Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated
(2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine. Mol Imaging. 2012; 11(4):
280-5.
Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki
N, Kimura G: Cardiac β-adrenergic receptor density and myocardial systolic
function in the remote noninfarcted region after prior myocardial infarction
with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012; 39:
1246-1253.
Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, YamaguchiS,
Houkin K, Tanaka S, Kuge Y, Tamaki N. 18F-Fluoromisonidazole positronemission
tomography may differentiate glioblastoma multiforme from lessmalignant
gliomas. Eur J Nucl Med Mol Imaging. 2012; 39(5): 760-70.
Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y,
Tamaki N: Intracerebral, but not intravenous, transplantation of bone marrow
stromal cells enhances functional recovery in rat cerebral infarct: An
optical imaging study. Neuropathology. 2012; 32(3): 217-26.
Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y,
Tamaki N, Sasaki H: Writing errors in ALS related to loss of neuronal integrity
in the anterior cingulate gyrus. J Neurol Sci. 2012; 315(1-2): 55-9.
Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y,
Houkin K, Tamaki N, Iwasaki Y: Therapeutic effects of intra-arterial delivery
of bone marrow stromal cells in traumatic brain injury of rats - In vivo
cell tracking study by near infrared fluorescence imaging. Neurosurgery.
2012; 70(2): 435-44; discussion 444.
Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki
N, Chiba H: A novel murine model for non-alcoholic steatohepatitis developedby
combination of a high-fat diet and oxidized low-density lipoprotein.Lab
Invest. 2012; 92(2): 265-81.
Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N,
Kuge Y: Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like
Peptide 1. Ann Nucl Med. 2012; 26(2): 184-91.
Hua Li, Songji Zhao, Yongnan Jin, Ken-ichi Nishijima, Hiromichi Akizawa,
Kazue Ohkura, Nagara Tamaki, Yuji Kuge: A radiolabeled uracil derivative
as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation
into tumor cells by target gene knockdown. Nucl Med Comn. 2011; 32 (12):
1211-5.
Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H: A Pre-targeting
Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based
Contrast Agents. Mol Imaging Biol. 2011; 13 (6): 1196-1203
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka
S, Kizaka-Kondoh S, Hiraoka M, Saji H: PET Imaging of Hypoxia-Inducible
Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable
Streptavidin and a Novel (18)F-Labeled Biotin Derivative. Mol Imaging Biol.
2011; 13 (5): 1003-10.
Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa
M, Tamaki N: Dynamic (11)C-methionine PET analysis has an additional value
for differentiating malignant tumors from granulomas: an experimental study
using small animal PET. Eur J Nucl Med Mol Imaging. 2011; 38(10): 1876-86.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N: Localization
of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with
Macrophage Infiltration but not Lipid Deposition in the Lesion. Mol Imaging
Biol. 2011; 13(4): 712-20.
Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M,
Iwasaki Y: Near-infrared fluorescence labeling allows non-invasive tracking
of bone marrow stromal cells transplanted into rat infarct brain. Neurosurgery.
2011; 68(4): 1036-47; discussion 1047.
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y,
Kinoshita I, Tamaki N, Dosaka-Akita H: 18F-Fluorothymidine PET/CT as an
early predictor of tumor response to treatment with cetuximab in human
lung cancer xenografts. Oncol Rep. 2011; 26: 725-730.
Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa
H, Shono Y, Saji H, Minematsu K, Tamaki N. Gene and protein analysis of
brain derived neurotrophic factor expression in relation to neurological
recovery induced by an enriched environment in a rat stroke model. Neurosci
Lett. 2011; 495(3): 210-215.
Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima
K, Kuge Y, Tamaki N: Semiquantitative analysis of C-11 methionine PET may
distinguish brain tumor recurrence from radiation necrosis even in small
lesions. Ann Nucl Med. 2011; 25(3): 213-20.
Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N: Performance characterization
of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality
imaging. Eur J Nucl Med Mol Imaging. 2011; 38(4): 742-52.
Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M,
Hirata K, Saji H, Tamaki N, Minematsu K: Gene expression associated with
an enriched environment after transient focal ischemia. Brain Res. 2011;
1376: 60-65
Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y,
Tamaki N: Regional partition coefficient of water in patients with cerebrovascular
disease and its effect on rCBF assessment. Nucl Med Commun. 2011; 32(1):
63-70.
Morimoto Y, Ueno Y, Takeuchi W, Kojima S, Matsuzaki K, Ishitsu T, Umegaki
K, Kiyanagi Y, Kubo N, Katoh C, Shiga T, Shirato H, Tamaki N. Development
of a 3D brain PET scanner using CdTe semiconductor detectors and its first
clinical application. IEEE Trans Nucl Sci. 58(5):2181-2189, 2011
Tamaki N, Kuge Y (eds.) :Molecular Imaging for Integrated Medical Therapy
and Drug Development. Springer (Springer Science+Business Media), Heidelberger,
2010.
【 著 書 】
Tamaki N, Kuge Y: Advances in Molecular Imaging. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development. In: Molecular Imaging
for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.1-4.
Kuge Y, Zhao S, Takei T, Tamaki N: Molecular Imaging for the Assessment
of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.19-29.
Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki
N: Initial Performance Measurement of an Integrated PET/SPECT/CT System
for Small Animal Imaging. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.60-68.
Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N: Molecular
Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG
and 99mTc-Annexin A5. In: Molecular Imaging for Integrated Medical Therapy
and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer Science+Business
Media), Heidelberger, 2010, pp.69-77.
Kuroda S, Kuge Y, Tamaki N, Iwasaki Y: Bone Marrow Stromal Cell Transplantation
for Central Nervous System Disorders Perspective for Translational Research
and Clinical Application. In: Molecular Imaging for Integrated Medical
Therapy and Drug Development (Tamaki N, Kuge Y eds.), Springer (Springer
Science+Business Media), Heidelberger, 2010, pp.126-138.
Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge
Y, Tamaki N, Iwasaki Y: Non-invasive Optical Tracking of Bone Marrow Stromal
Cells Transplanted into Rat Cerebral Infarct. In: Molecular Imaging for
Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.),
Springer (Springer Science+Business Media), Heidelberger, 2010, pp.139-144.
Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K,
Ohkura K: In vitro and in vivo evaluations of a radioiodinated thymidine
phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme
imaging. Nuclear Medicine and Biology 37(4): 427-432, 2010.3
Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H: Radioimmunodetection of membrane
type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting
method. Biol.Pharm.Bull 33(9): 1589-1595, 2010.9
Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H,
Kuge Y, Saji H: Nicotinic acetylcholine receptors expressed in the ventralposterolateral
thalamic nucleus play an important role in anti-allodynic effects. Br J
Pharmacol. 2010; 159: 1201 - 1210.
Seki KI, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K: Isolation
and identification of new vasodilative substances in diesel exhaust particles.
Environ Sci Pollut Res Int. 2010;17(3):717-23.
Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H: Synthesis of a New
NIR Fluorescent Nd Complex Labeling Agent. J Fluoresc. 2010; 20(1):225-34.
Aita K, Temma T, Kuge Y, Seki KI, Saji H: NIR fluorescent ytterbium compound
for in vivo fluorescence molecular imaging. Luminescence. 2010; 25: 19-24.
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono
M, Saji H: Tissue factor detection for selectively discriminating unstable
plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51(12): 1979-1986.
Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi
J, Kiyono Y, Shiomi M, Saji H: Imaging with radiolabelled anti-membrane
type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing
atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2010; 37(11): 2093-2104.
Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M,
Kizaka-Kondoh S, Hiraoka M, Saji H: Rapid detection of hypoxia-inducible
factor-1-active tumours: pretargeted imaging with a protein degrading in
a mechanism similar to hypoxia-inducible factor-1alpha. Eur J Nucl Med
Mol Imaging. 2010;37(8):1566-1574.